期刊
BEHAVIOURAL BRAIN RESEARCH
卷 421, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2021.113713
关键词
Novel psychoactive substances; Naphyrone; Conditioned place preference test; CPP; Addictive potential
资金
- Grant Agency of Charles University in Prague, Czech Republic [GAUK 882217]
- Safety Research under the Czech Ministry of the Interior [VI20172020056]
- Czech Science Foundation [18-16218S, 20-25349S]
- Czech Health Research Council [17-31852A, NU21-04-00307]
- Long-term conceptual development of research organization [RVO 00023752]
- Specific University Research, Czech Ministry of Education, Youth and Sports [260533/SVV/2021]
This study aimed to evaluate the addictive potential of Naphyrone in rats and found that it has addictive properties and poses a significant risk to users.
Naphyrone, also known as NRG-1, is a novel psychoactive substance (NPS), a cathinone with stimulatory properties available on the grey/illicit drug market for almost a decade. It is structurally related to infamously known powerful stimulants with the pyrovalemne structure, such as alpha-pyrrolidinovalemphenone (alpha-PVP) or methylenedioxypyrovalemne (MDPV) that are labeled as a cheap replacement for cocaine and other stimulants. Despite the known addictive potential of alpha-PVP and MDPV, there are no studies directly evaluating naphyrone's addictive potential e.g., in conditioned place preference (CPP) test or using self-administration. Therefore, our study was designed to evaluate the addictive potential in a CPP test in male Wistar rats and compare its effect to another powerful stimulant with a high addictive potential - methamphetamine. Naphyrone increased time spent in the drug-paired compartment with 5 and 20 mg/kg s.c. being significant and 10 mg/kg s.c. reaching the threshold (p = 0.07); the effect was comparable to that of methamphetamine 1.5 mg/kg s.c. The lowest dose, naphymne 1 mg/kg s.c., had no effect on CPP. Interestingly, no dose response effect was detected. Based on these data, we are able to conclude that naphyrone has an addictive potential and may possess a significant risk to users.
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