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Tangui Maurice
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
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JOURNAL OF NEUROCHEMISTRY (2021)
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SCIENCE TRANSLATIONAL MEDICINE (2021)
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ELIFE (2020)
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
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NEURON (2020)
Sigma-1 (sigma(1)) receptor activity is necessary for physiological brain plasticity in mice
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EUROPEAN NEUROPSYCHOPHARMACOLOGY (2020)
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ELIFE (2020)
Effects of Pridopidine on Functional Capacity in Early-Stage Participants from the PRIDE-HD Study
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JOURNAL OF HUNTINGTONS DISEASE (2020)
Sigma-1 receptor chaperones rescue nucleocytoplasmic transport deficit seen in cellular and Drosophila ALS/FTD models
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NATURE COMMUNICATIONS (2020)
Additional Safety and Exploratory Efficacy Data at 48 and 60 Months from Open-HART, an Open-Label Extension Study of Pridopidine in Huntington Disease
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JOURNAL OF HUNTINGTONS DISEASE (2020)
Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress
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NEUROTOXICITY RESEARCH (2019)
Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study
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NEUROTHERAPEUTICS (2019)
Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model
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CELL DEATH & DISEASE (2019)
Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo
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CELLS (2019)
Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor
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NEUROBIOLOGY OF DISEASE (2019)
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FRONTIERS IN PHARMACOLOGY (2019)
Simvastatin aggravates impaired autophagic flux in NSC34-hSOD1G93A cells through inhibition of geranylgeranyl pyrophosphate synthesis
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NEUROSCIENCE (2019)
Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor
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NEUROBIOLOGY OF DISEASE (2019)
Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation
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FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)
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ELIFE (2019)
Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques
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MOVEMENT DISORDERS (2019)
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
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CELL (2018)
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EMBO JOURNAL (2018)
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NATURE NEUROSCIENCE (2018)
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NEUROPHARMACOLOGY (2018)
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NEUROPHARMACOLOGY (2018)
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NATURE COMMUNICATIONS (2018)
Sigma Receptors as Endoplasmic Reticulum Stress Gatekeepers and their Modulators as Emerging New Weapons in the Fight Against Cancer
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FRONTIERS IN PHARMACOLOGY (2018)
Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import
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CELL (2018)
Sigma 1 receptor: A novel therapeutic target in retinal disease
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PROGRESS IN RETINAL AND EYE RESEARCH (2018)
The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats
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JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission
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NATURE COMMUNICATIONS (2017)
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
Michela Palmieri et al.
NATURE COMMUNICATIONS (2017)
Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice
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JCI INSIGHT (2017)
Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder
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EMBO JOURNAL (2017)
The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins
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CELL DEATH AND DIFFERENTIATION (2017)
Pridopidine activates neuroprotective pathways impaired in Huntington Disease
Michal Geva et al.
HUMAN MOLECULAR GENETICS (2016)
Crystal structure of the human σ1 receptor
Hayden R. Schmidt et al.
NATURE (2016)
σ1 receptor ligands control a switch between passive and active threat responses
Andrew J. Rennekamp et al.
NATURE CHEMICAL BIOLOGY (2016)
Toward the atomic structure of the nuclear pore complex: when top down meets bottom up
Andre Hoelz et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration
Jing Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems
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TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Toward the atomic structure of the nuclear pore complex: when top down meets bottom up
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment
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ENVIRONMENTAL HEALTH (2015)
Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS
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JOURNAL OF CELL SCIENCE (2015)
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NATURE (2015)
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
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NATURE (2015)
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism
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NATURE (2015)
Subcellular Localization of the Sigma-1 Receptor in Retinal Neurons - an Electron Microscopy Study
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SCIENTIFIC REPORTS (2015)
Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism
Veronica Francardo et al.
BRAIN (2014)
The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands
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JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
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NATURE (2014)
Neuroprotective effects of the Sigma-1 receptor (SIR) agonist PRE-084, in a mouse model of moter neuron disease not linked to SOD1 mutation
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NEUROBIOLOGY OF DISEASE (2014)
Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances
J. T. Vollrath et al.
CELL DEATH & DISEASE (2014)
Photoaffinity Labeling of the Sigma-1 Receptor with N-[3-(4-Nitrophenyl)propyl]-N-dodecylamine: Evidence of Receptor Dimers
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BIOCHEMISTRY (2013)
Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway
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CELL DEATH & DISEASE (2013)
Sigma-1R Agonist Improves Motor Function and Motoneuron Survival in ALS Mice
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NEUROTHERAPEUTICS (2012)
A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis
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ANNALS OF NEUROLOGY (2011)
Insight into Structure and Assembly of the Nuclear Pore Complex by Utilizing the Genome of a Eukaryotic Thermophile
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CELL (2011)
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
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NEURON (2011)
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
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NEURON (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
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SCIENCE (2011)
THE SIGMA-1 RECEPTOR IS ENRICHED IN POSTSYNAPTIC SITES OF C-TERMINALS IN MOUSE MOTONEURONS. AN ANATOMICAL AND BEHAVIORAL STUDY
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NEUROSCIENCE (2010)
The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator
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SCIENCE (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
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SCIENCE (2009)
Sigma-1 receptor chaperones at the ER-Mitochondrion interface regulate Ca2+ signaling and cell survival
Teruo Hayashi et al.
CELL (2007)
Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus
JE Bermack et al.
SYNAPSE (2005)
Nuclear pore complex structure and dynamics revealed by cryoelectron tomography
M Beck et al.
SCIENCE (2004)
Clinical trials with sigma ligands
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PHARMACOPSYCHIATRY (2004)