Palmitoylation facilitates inflammation through suppressing NOD2 degradation mediated by the selective autophagy receptor SQSTM1

Summary: This study reveals that S-palmitoylation influences the stability of NOD2. Inhibition of S-palmitoylation leads to SQSTM1/p62-mediated autophagic degradation of NOD2, while S-palmitoylation of NOD2 by ZDHHC5 promotes its stability. Furthermore, a gain-of-function variant of NOD2, NOD2s-R444C, with high S-palmitoylation level induces excessive inflammation.