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Article
Engineering, Biomedical
Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy
Xiao-Yan Fan et al.
Summary: Forced mitophagy can reduce mtDNA carryover in mitochondrial replacement therapy by pre-labelling the mitochondrial outer membrane of a donor zygote with an autophagy receptor, as shown in mouse and human embryos.
NATURE BIOMEDICAL ENGINEERING (2022)
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