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Article
Neurosciences
John N. Wood
Summary: Burnstock's contributions to the discovery and significance of purinergic neurotransmission in pain research have been crucial in expanding our knowledge in this field. His mechanistic insights have profound implications for understanding the pain system and highlight his role as a pioneer in biomedical progress.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2022)
Article
Neurosciences
Charles Kennedy
Summary: Geoff Burnstock's scientific legacy includes the identification of ATP as a neurotransmitter in the gut, the discovery of a large family of receptors, and the demonstration of ATP's role as an excitatory cotransmitter in autonomic nerves. The potential therapeutic application of cotransmission in treating dysfunctional bladder disorders is a promising area of research.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Alexander V. Gourine et al.
Summary: This article summarizes the experimental studies on the mechanisms controlling breathing and chemosensory ATP release in the central nervous system, highlighting the role of astrocytes in conditions of increased metabolic demand and emphasizing the importance of purinergic signalling in regulating communication between astrocytes and neurons.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Anthony P. Ford et al.
Summary: Gefapixant, also known as MK-7264, is the first clinically developed antagonist for the P2X3 subtype of ionotropic purinergic receptors. It has successfully completed Phase 3 investigations for the treatment of cough and is now under review for approval by the US FDA. Developed initially by Roche Pharmaceuticals, clinical development was continued by Afferent Pharmaceuticals before being acquired by Merck & Co., Inc.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Christopher H. Fry et al.
Summary: This passage summarizes the research on the role of ATP and purines in urinary tract physiology over the past fifty years, focusing on the modulation of urinary tract function by purines and purinergic signaling mechanisms.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
T. Finger et al.
Summary: Taste buds are made up of specialized epithelial cells that detect specific tastants and release ATP as a neurotransmitter onto nerve fibers. Despite recent discoveries, there are still several aspects of purinergic transmission in the taste system that need further elucidation.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Marcello Costa et al.
Summary: The enteric nervous system controls the movement and mixing of nutrients in the digestive tract through excitatory and inhibitory motor neurons, with inhibitory motor neurons playing a role in muscle relaxation and propulsion. IMNs are located in the myenteric plexus and act by relaxing the circular muscle to facilitate propulsion, with ongoing activity to maintain muscle relaxation and respond to content for further activation of enteric pathways.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Madeleine R. Di Natale et al.
Summary: Smooth muscle tissue is composed of numerous small, electrically connected muscle cells, each influenced by multiple axons. While the probability of an individual varicosity releasing transmitter onto adjacent muscle cells is low, multiple axons can influence a single muscle cell.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Brian F. King
Summary: The ATP analogue alpha, beta-meATP is a potent relaxant of gastrointestinal smooth muscle, acting through Ca2+-permeable P2X3 receptors to release inhibitory nucleotides like ATP and beta-NAD, leading to P2Y1-mediated brief relaxations, as well as another transmitter (possibly NO) causing prolonged relaxations. Prejunctional P2X3 receptors serve as a purinergic feed-forward mechanism to enhance the action of inhibitory nerves on gut motility.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Emma N. Bardsley et al.
Summary: Changes in oxygen levels have significant impact on the evolution of biological complexity, with oxygen being essential for ATP production in eukaryotic cells. Higher mammals have developed specialized organs to maintain oxygen levels for survival. Sensitivity of ATP transmission increases in the carotid body under hypoxic conditions.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Nick J. Spencer et al.
Summary: The article highlights the extraordinary accomplishments of the partnership between Geoff Burnstock and Mollie Holman in autonomic neuroscience in Australia. It emphasizes the importance of being open to criticism, respecting peer opinions, and cultivating a constructive scientific spirit. Their legacy includes nurturing a new generation of researchers who have made significant discoveries in the field.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Review
Physiology
Volker Vallon et al.
PHYSIOLOGICAL REVIEWS
(2020)
Review
Physiology
Kenton M. Sanders et al.
Review
Pharmacology & Pharmacy
Geoffrey Burnstock
CURRENT PHARMACEUTICAL DESIGN
(2009)
