期刊
ATHEROSCLEROSIS
卷 349, 期 -, 页码 190-195出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2021.09.027
关键词
Lipoprotein(a); Coronary artery disease; Atherosclerosis; Heart disease risk factors; Coronary computed tomography angiography
资金
- Ulsan University Hospital Research Grant [UUH-2019-07]
- Medical data-driven hospital support project, through the Korea Health Information Service (KHIS) - Ministry of Health & Welfare, Republic of Korea
In asymptomatic individuals, higher levels of Lp(a) are associated with subclinical coronary atherosclerosis. The severity and extent of coronary plaques increase with higher levels of Lp(a).
Background and aims: There are limited data regarding the association between lipoprotein(a) (Lp[a]) and subclinical coronary atherosclerosis. This study investigated the association between Lp(a) and subclinical coronary atherosclerosis detected by coronary computed tomographic angiography (CCTA) in an asymptomatic population. Methods: We retrospectively analyzed 7201 asymptomatic individuals (mean age 54.4 +/- 7.9 years; 65.3% men with no prior history of coronary artery disease who voluntarily underwent CCTA as part of a general health examination). The degree and extent of subclinical coronary atherosclerosis were evaluated by CCTA. Study participants were stratified into quartiles according to their Lp(a) levels (<4.3, 4.3-8.9, 9.0-20.1, and >20.2 mg/ dL). Results: Of the study participants, any coronary plaque on CCTA was observed in 2557 (35.5%). Specifically, calcified, non-calcified, and mixed plaques were observed in 2411 (33.5%), 363 (5.0%) and 249 (3.5%) participants, respectively. After adjustment for the presence of cardiovascular risk factors, the fourth Lp(a) quartile was significantly associated with any coronary (odds ratio [OR] 1.212; 95% confidence interval [CI] 1.038-1.416), calcified (1.205, 95% CI 1.030-1.410), non-calcified (1.588, 95% CI 1.152-2.189), or mixed (1.674, 95% CI 1.172-2.391) plaque compared with the first Lp(a) quartile. In addition, 442 (6.1%) had significant coronary artery stenosis (>50% diameter stenosis). The odds ratio for significant stenosis (1.537, 95% CI 1.153-2.048) was higher in the fourth quartile compared with the first quartile. Conclusions: In this large cross-sectional study with asymptomatic individuals undergoing CCTA, higher Lp(a) level was associated with subclinical coronary atherosclerosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据