期刊
ISME JOURNAL
卷 10, 期 8, 页码 2072-2075出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ismej.2015.251
关键词
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资金
- Zhejiang Provincial Natural Science Foundation of China [R13C140001]
- National Natural Science Foundation of China [31571971, 31371904, 31200003]
- Zhejiang Provincial Project [2014C32010]
- Fundamental Research Funds for the Central Universities
- Agricultural Ministry of China [nyhyzx 201303015, 201003029, 201003066]
- Key Subject Construction Program of Zhejiang for Modern Agricultural Biotechnology and Crop Disease Control [2010DS700124-KF1101, 2010DS700124-KF1203, 2010DS700124-KF1309, 2010DS700124-KF1410]
Different lifestyles, ranging from a saprophyte to a pathogen, have been reported in bacteria of one species. Here, we performed genome-wide survey of the ecological adaptation in four Burkholderia seminalis strains, distinguished by their origin as part of the saprophytic microbial community of soil or water but also including human and plant pathogens. The results indicated that each strain is separated from the others by increased fitness in medium simulating its original niche corresponding to the difference between strains in metabolic capacities. Furthermore, strain-specific metabolism and niche survival was generally linked with genomic variants and niche-dependent differential expression of the corresponding genes. In particular, the importance of iron, trehalose and D-arabitol utilization was highlighted by the involvement of DNA-methylation and horizontal gene transfer in niche-adapted regulation of the corresponding operons based on the integrated analysis of our multi-omics data. Overall, our results provided insights of niche-specific adaptation in bacteria.
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