期刊
ASIAN JOURNAL OF SURGERY
卷 46, 期 1, 页码 360-365出版社
ELSEVIER SINGAPORE PTE LTD
DOI: 10.1016/j.asjsur.2022.04.075
关键词
Gastric carcinoma; -Inflammatory markers; -Prognosis; -Survival
类别
This study aimed to determine the prognostic values of preoperative inflammatory biomarkers in patients undergoing curative surgery for gastric carcinoma and contribute to the development of prognostic modeling. The medical data of 91 patients who underwent gastrectomy for gastric carcinoma were retrospectively analyzed. The results showed that preoperative inflammatory markers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lactate dehydrogenase albumin ratio (LAR), and advanced tumor stage had adverse effects on the survival of gastric carcinoma patients. Further studies with larger sample sizes are needed to validate these findings.
Background: It is aimed to determine the prognostic values of preoperative inflammatory biomarkers in patients undergoing curative surgery for gastric carcinoma and to contribute to the development of prognostic modeling.Objective: To investigate the effect of various different preoperative inflammatory markers on the prognosis of gastric carcinoma. Material and method: The medical data and the mortality status of 91 patients who underwent total or subtotal gastrectomy operation for gastric carcinoma at Mersin City Training and Research Hospital between 2016 and 2020 were retrospectively reviewed from the hospital records and patient files. The patients' demographic characteristics, tumor location, histopathological diagnosis, pathological stage, tumor markers, and preoperative inflammatory and hematological markers were analyzed. Based on these data, tumor stage, metastatic lymph node ratio (MLR), lactate dehydrogenase albumin ratio (LAR), neutrophil-lymphocyte ratio (NLR), and platelet lymphocyte ratio (PLR) were calculated. The relationship between these parameters and postoperative survival was analyzed. Statistical analyses were performed with IBM SPSS for Windows, version 17.0 (IBM Corporation, Armonk, New York, United States).Results: The correlation analysis of the parameters affecting survival showed that, in addition to an advanced tumor stage, inflammatory parameters like NLR, PLR, and LAR adversely affected survival.Conclusion: Preoperative NLR, PLR, LAR, and advanced tumor stage may help determine the survival of gastric carcinoma patients. Multiple studies with larger series are needed on this subject.(c) 2022 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V.
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