期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 42, 期 3, 页码 E74-E84出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.121.316093
关键词
atherosclerosis; cardiovascular diseases; clone cells; macrophages; vascular smooth muscle
资金
- National Institutes of Health [R01 HL084312]
- Perpetual IMPACT grant
Clonal expansion plays a crucial role in atherosclerosis, particularly in smooth muscle cells and macrophages. Recent studies have revealed the contribution of clonal expansion to disease pathology and provided innovative directions for future therapies of atherosclerosis and associated cardiovascular diseases.
Clonal expansion is a process that can drive pathogenesis in human diseases, with atherosclerosis being a prominent example. Despite advances in understanding the etiology of atherosclerosis, clonality studies of vascular cells remain in an early stage. Recently, several paradigm-shifting preclinical studies have identified clonal expansion of progenitor cells in the vasculature in response to atherosclerosis. This review provides an overview of cell clonality in atherosclerotic progression, focusing particularly on smooth muscle cells and macrophages. We discuss key findings from the latest research that give insight into the mechanisms by which clonal expansion of vascular cells contributes to disease pathology. The further probing of these mechanisms will provide innovative directions for future progress in the understanding and therapy of atherosclerosis and its associated cardiovascular diseases.
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