期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 42, 期 6, 页码 E168-E185出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATV.0000000000000153
关键词
AHA Scientific Statements; cardiovascular diseases; diabetes mellitus; hepatocytes; hypertriglyceridemia; insulin resistance; metabolic syndrome; nonalcoholic fatty liver disease; triglycerides
Nonalcoholic fatty liver disease is a common chronic condition that is often undetected until it progresses to serious complications, such as liver cirrhosis and hepatocellular carcinoma. It is also a risk factor for atherosclerotic cardiovascular disease.
Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is believed to affect >25% of adults worldwide. Unless specific testing is done to identify NAFLD, the condition is typically silent until advanced and potentially irreversible liver impairment occurs. For this reason, the majority of patients with NAFLD are unaware of having this serious condition. Hepatic complications from NAFLD include nonalcoholic steatohepatitis, hepatic cirrhosis, and hepatocellular carcinoma. In addition to these serious complications, NAFLD is a risk factor for atherosclerotic cardiovascular disease, which is the principal cause of death in patients with NAFLD. Accordingly, the purpose of this scientific statement is to review the underlying risk factors and pathophysiology of NAFLD, the associations with atherosclerotic cardiovascular disease, diagnostic and screening strategies, and potential interventions.
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