Herbicide Roundup shows toxic effects in nontarget organism Drosophila

Glyphosate-based herbicide Roundup, as the most employed herbicide used for multiple purposes in agriculture, adversely affects nontarget organisms. We tested the effects of Roundup applied at larval and adult stages. Roundup caused developmental delay and increased larvae mortality. Roundup treatment reduced hemolymph glucose and glycogen levels in adult flies of both sexes at the highest concentration tested. Sex-dependent diverse effects were found in catalase and Cu,Zn superoxide dismutase (Cu,Zn-SOD) activities. Decreased aconitase activity, contents of thiols, and lipid peroxides were found after larval Roundup exposure. Furthermore, chronic exposure to adult flies decreased appetite, body weight, and shortened lifespan. Thus, our results suggest that high concentrations of Roundup are deleterious to both larvae and adults, resulting in a shift of the metabolism and antioxidant defense system in Drosophila melanogaster.

Automated summary

Glyphosate-based herbicide Roundup has adverse effects on both larvae and adults of Drosophila melanogaster, causing developmental delay, increased mortality, altered glucose and glycogen levels, and changes in antioxidant defense system. Chronic exposure to adult flies also results in decreased appetite, body weight, and shortened lifespan.