4.5 Review

Thiophene-containing compounds with antimicrobial activity

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ARCHIV DER PHARMAZIE
卷 355, 期 6, 页码 -

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.202100462

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antibacterial; antifungal; drug design; structure-activity relationship; thiophene

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This review provides a comprehensive account of the developments in the field of antimicrobial compounds featuring at least one thiophene ring in their structure over the last decade.
Thiophene, as a member of the group of five-membered heterocycles containing one heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the accurate positioning of various functionalities onto the thiophene ring. This review provides a comprehensive, systematic and detailed account of the developments in the field of antimicrobial compounds featuring at least one thiophene ring in their structure, over the last decade.

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