4.7 Article

NLRP3 is a promising target for regulating high glucose-induced inflammatory response in Megalobrama amblycephala

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Summary: This study characterized the full-length cDNA of thioredoxin-interacting protein (TXNIP) from Megalobrama amblycephala and investigated its roles in high glucose-induced inflammatory response. Txnip expression was found to increase in liver and white muscle under a high-carbohydrate diet, while insulin injection led to a decrease in txnip expression. In vitro studies showed that over-expression of txnip increased il-1 beta and il-6 expression in hepatocytes, while knockdown reduced il-1 beta expression. Metformin treatment increased cell viability and trx expression, and decreased ROS levels and other factors under high glucose conditions.

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