期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 89, 期 -, 页码 42-56出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2015.06.007
关键词
Optical microscopy; Tip-enhanced Raman; High resolution; Nucleic acids; Lipids; Proteins; TERS applications
资金
- DFG [GRK 1257/2]
- Thuringer Aufbaubank [FKZ: 2011 FE 9048, 2011 VF 0016]
Tip-enhanced Raman scattering (TERS) has become a powerful tool for nanoscale structural analysis for several branches of organic, inorganic, and biological chemistry. This highly sensitive technique enables molecular characterization with a lateral resolution far beyond Abbe's diffraction limit and correlates structural and topographic information on a nanometer scale. In this review, the current experimental concepts with respect to their strengths and obstacles are introduced and discussed. A further focus was set to biochemistry comprising applications like nucleic acids, proteins, and microorganisms, thus demonstrating the potential use towards the pharmaceutically relevant challenges where nanometer resolution is required. (C) 2015 Elsevier B.V. All rights reserved.
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