4.5 Article

Adhesionable flexible GaN-based microLED array film to brain surface for in vivo optogenetic stimulation

期刊

APPLIED PHYSICS EXPRESS
卷 15, 期 4, 页码 -

出版社

IOP Publishing Ltd
DOI: 10.35848/1882-0786/ac5ba3

关键词

microLED; optogenetics; flexible device; transfer technology

资金

  1. JST PRESTO [JPMJPR1885]
  2. Okinawa Institute of Science and Technology Kick-start fund
  3. Murata Science Foundation
  4. Daiko Foundation
  5. Casio Science Promotion Foundation
  6. Research Foundation for OptoScience and Technology
  7. Takeda Science Foundation
  8. Tochigi Industrial Promotion Center

向作者/读者索取更多资源

In this study, a biocompatible optical stimulation device was developed that can adhere to the brain surface and activate spatially separated brain regions. By using a hollow structure and a thermal release sheet, microLEDs were successfully transferred onto a biocompatible parylene film without any rotation or misalignment while retaining their characteristics.
A development of a biocompatible, optical stimulation device capable of adhering to the brain surface and activating spatially separated brain regions is necessary for in vivo optogenetic applications. In this study, a hollow structure for isolating the microLED epitaxial layer was fabricated using the anisotropic KOH wet-etching method. Using a thermal release sheet, a method to transfer microLEDs onto a biocompatible parylene film was established without rotation or misalignment of the microLEDs while retaining their characteristics. Accordingly, a flexible microLED array film was fabricated, which adhered to the surface of the brain of a mouse and exhibited blue emission.

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