Quinoline-fused both non-peripheral and peripheral ZnII and MgII phthalocyanines: Anti-cholinesterase, anti-α-glucosidase, DNA nuclease, antioxidant activities, and in silico studies

Quinoline-fused Zn-II (ZnPcp/ZnPcnp) and Mg-II (MgPcp/MgPcnp) phthalocyanines with four 4-methylquinolin-2-ol (1) at non-peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization of phthalonitrile derivatives (CNp/CNnp) in the presence of zinc (II) and magnesium (II) metal ions in this study. After synthesis and characterization processes, anti-cholinesterase, anti-alpha-glucosidase, DNA nuclease, antioxidant activities, and in silico calculations of both peripheral and non-peripheral Zn-II and Mg-II phthalocyanines were investigated. The inhibitory effects of metallated phthalocyanines on acetylcholinesterase, butyrylcholinesterase, and alpha-glucosidase enzymes were tested by spectrophotometric method. Theoretical methods are used to compare both the chemical and biological activities of the studied phthalonitrile derivatives and metallated phthalocyanine compounds.

Automated summary

In this study, quinoline-fused phthalocyanine compounds with 4-methylquinolin-2-ol were synthesized and their anti-enzyme activity, antioxidant activity, and DNA nuclease activity were investigated. The chemical and biological activities of the synthesized compounds were compared using theoretical methods.