期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 106, 期 8, 页码 2927-2935出版社
SPRINGER
DOI: 10.1007/s00253-022-11914-1
关键词
Talaromyces; Meroterpenoid; Cytotoxic; Antibacterial
资金
- Natural Science Foundation of Fujian Province [2021J01509]
- Scientific Research Foundation of Third Institute of Oceanography SOA [2018021]
- National Natural Science Foundation of China [81903842, 41906104]
- Deep Sea Habitats Discovery Project [DY-XZ-04]
- Research project on education and teaching reform in undergraduate colleges and universities of Fujian Province [FBJG20190201]
- Natural Science Foundation of Zhejiang Province [LR21H280001, Q22H287247]
- COMRA program [DY135-B2-01, DY135B2-05]
- Scientific Research Foundation of Third Institute of Oceanography MNR [2019021]
A new meroterpenoid, taladrimanin A (1), was isolated from a marine-derived fungus, and its structure and activity were studied. Compound 1 showed inhibitory activity against gastric cancer cells and certain bacteria.
A new meroterpenoid, taladrimanin A (1), was isolated from a marine-derived fungus Talaromyces sp. HM6-1-1, together with eleven biogenetically related compounds (2-12). A plausible biosynthetic pathway for the meroterpenoids (1-4) was proposed. The planar structure of 1 was assigned by HRESIMS and NMR. Its relative configuration was established by quantum chemical NMR calculation of two possible isomers and analyzed by DP4 + method. Finally, X-ray diffraction unambiguously confirmed the relative configuration and revealed the absolute configuration of compound 1. 2-12 were assigned by comparing their NMR data with those reported in the literature. 1 was the first drimane-type meroterpenoid with a C10 polyketide unit bearing an 8R-configuration. In the bioactive assay, 1 exhibited antitumor activity against gastric cancer cells MGC803 and MKN28; it also inhibited the colony formation and induced apoptosis in MGC803 cells both in a concentration-dependent manner. Additionally, 1 displayed selective antibacterial activity against Staphylococcus aureus 6538P, and low activities towards strains of Vibrio parahaemolyticus and Escherichia coli in this study.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据