期刊
APPLIED CLAY SCIENCE
卷 222, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.clay.2022.106489
关键词
Halloysite nanotubes; Maltodextrin; Blackthorn; Polyphenols; Encapsulation; Cytotoxicity
资金
- Science Fund of the Republic of Serbia [7731993]
- Ministry of Education, Science and Technological Development, Republic of Serbia [451-03-68/2022-14/200117]
- Provincial Secretariat for Higher Education and Scientific Research of the Autonomous Province of Vojvodina [142-451-3082/2020-3]
In this study, halloysite and maltodextrin were used as encapsulating agents to encapsulate the active ingredients in blackthorn extract. The experiments showed that these encapsulates had anti-cancer effects on tumor cells and prolonged the release of blackthorn bioactives. Therefore, blackthorn extract and its encapsulates have great potential in the production of functional foods and pharmaceuticals.
Halloysite, as an inorganic nanoclay material, maltodextrin, as a carbohydrate polymer, and the composite made of them were tested as encapsulating agents for blackthorn (Prunus spinosa L.) extract rich in phenolic acids and anthocyanins. For the halloysite nanotubes loading cyclic vacuum technique was applied, and maltodextrin encapsulates were prepared by freeze-drying process. Thermogravimetric analysis confirmed that blackthorn extract was encapsulated with halloysite, maltodextrin, and maltodextrin-halloysite composite. The cytotoxic effect of the encapsulates was tested in tumor (MCF7 and HT-29) and non-tumor (MRC-5) cells. The release of four major phenolic compounds: 3-O-caffeoylquinic acid (neochlorogenic acid) and, cyanidin 3-O-glucoside, cyanidin 3-O-rutinoside, and peonidin 3-O-rutinoside was tested. Addition of extract and encapsulates in yoghurt prolonged the release of blackthorn bioactives. These results indicate that blackthorn extract and its halloysite and maltodextrin encapsulates have potential in the production of functional foods, food supplements, and pharmaceuticals.
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