期刊
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s12010-022-03960-2
关键词
Alpinetin; Anticancer mechanism; Apoptosis; Cell signaling; Chemosensitizer
资金
- National Natural Science Foundation of China [81672944]
- Innovation team of Six Talent Peaks Project in Jiangsu Province [WSN-062]
- priority academic program, development of Jiangsu Higher Education Institutions (Integration of Chinese and Western Medicines)
The review compiles data on the natural sources of Alpinetin (ALPI) and its anticancer activity in various human cancers, highlighting its potential as a bioactive dietary nutraceutical. It sets the stage for further pre-clinical and clinical trials to develop ALPI as a lead structure for oncological therapy.
Cancer is a global burden and mechanistically complex disease with a plethora of genetic, physiological, metabolic, and environmental alterations. The development of dietary nutraceuticals into cancer chemotherapeutics has emerged as a new paradigm in cancer treatment. Alpinetin (ALPI) is a novel flavonoid component of multiple edible and medicinal plants and possesses a wide range of biological and pharmacological activities including antibacterial, anti-hemostatic, anti-oxidative, anti-hepatotoxic, stomachic, immunosuppressive, and anti-inflammatory. Recently, ALPI has been reported as a bioactive dietary nutraceutical with promising anticancer activity in various human cancers through multiple mechanisms. The purpose of this review is to compile the data on natural sources of ALPI, and its anticancer activity including cellular targets and anticancer mechanism in various human cancers. Moreover, this review will set the stage for further design and conduct pre-clinical and clinical trials to develop ALPI into a lead structure for oncological therapy.
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