Bone Penetration of Cycloserine in Osteoarticular Tuberculosis Patients of China

The cycloserine concentrations in plasma and bone that were collected during operations on 28 osteoarticular tuberculosis (TB) patients treated daily with a 500-mg cycloserine-containing regimen were determined. The median concentrations in plasma and bone were 1629 mu g/mL (interquartile range [IQR], 6.47 mu g/mL) and 2433 mu g/g (IQR, 14.68 mu g/g), respectively. The median bone/plasma penetration ratio was 0.76 (range, 033 to 1.98). Cycloserine could effectively penetrate bone and acquire concentrations comparable to those in plasma, which favors its usage in osteoarticular TB treatment.

Automated summary

The study found that cycloserine can effectively penetrate into the bone and achieve concentrations comparable to those in plasma in patients undergoing osteoarticular tuberculosis surgery. This is beneficial for the treatment of osteoarticular tuberculosis.