期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 22, 期 16, 页码 2876-2884出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520622666220324094033
关键词
Human serum albumin; anti-cancer drugs; distribution of drugs; pharmacokinetics; Sudlow's site II; subdomain II A
The interaction between drugs and proteins is crucial for drug distribution. Human serum albumin (HSA), the most abundant protein in the human body, plays a significant role in the pharmacokinetics of many drugs. This article summarizes the binding properties of some anti-cancer drugs with HSA, specifically highlighting the binding site in subdomain II A, known as Sudlow's site I, where more drugs bind compared to Sudlow's site II.
The interaction of drugs with proteins plays a very important role in the distribution of the drug. Human serum albumin (HSA) is the most abundant protein in the human body, showing great binding characteristics, and has gained a lot of importance pharmaceutically. It plays an essential role in the pharmacokinetics of a number of drugs; hence, several reports are available on the interaction of drugs with HSA. It can bind to cancer drugs; thus, it is crucial to look at the binding characteristics of these drugs with HSA. Herein, we summarize the binding properties of some anti-cancer drugs by specifically looking into the binding site with HSA. The number of drugs binding at the Sudlow's site I situated in subdomain II A is more than the drugs binding at Sudlow's site II.
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