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Interdependency and Redundancy Add Complexity and Resilience to Biogenesis of Bacterial Ribosomes

期刊

ANNUAL REVIEW OF MICROBIOLOGY
卷 76, 期 -, 页码 193-210

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ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-041020-121806

关键词

ribosomal subunit; ribosomal intermediates; quality control; assembly; biogenesis; maturation

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  1. University of Rochester
  2. National Institute of General Medical Sciences (NIGMS)

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The production of ribosomal subunits directly affects the fitness of bacteria, and extra-ribosomal protein factors play a crucial role in this process.
The pace and efficiency of ribosomal subunit production directly impact the fitness of bacteria. Biogenesis demands more than just the union of ribosomal components, including RNA and proteins, to form this functional ribonucleoprotein particle. Extra-ribosomal protein factors play a fundamental role in the efficiency and efficacy of ribosomal subunit biogenesis. A paucity of data on intermediate steps, multiple and overlapping pathways, and the puzzling number of functions that extra-ribosomal proteins appear to play in vivo make unraveling the formation of this macromolecular assemblage difficult. In this review, we outline with examples the multinodal landscape of factor-assisted mechanisms that influence ribosome synthesis in bacteria. We discuss in detail late-stage events that mediate correct ribosome formation and the transition to translation initiation and thereby ensure high-fidelity protein synthesis.

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