Current Developments and Challenges of mRNA Vaccines

mRNA. vaccines have brought about a great revolution in the vaccine fields owing to their simplicity and adaptability in antigen design, potential to induce both humoral and cell-mediated immune responses and demonstrated high efficacy; and rapid and low-cost production by using the same manufacturing platform for different mRNA vaccines. Multiple mRNAvaccines have been investigated for both infectious diseases and cancers, showing significant superiority to other types of vaccines. Although great success of mRNA vaccines has been achieved in the control of the coronavirus disease 2019 pandemic, there are still multiple challenges for the future development of mRNA vaccines. In this review, the most recent developments of mRNA vaccines against both infectious diseases and cancers are summarized for an overview of this field. Moreover, the challenges are also discussed on the basis of these developments.

Automated summary

mRNA vaccines have revolutionized the vaccine field with advantages in antigen design, immune response induction, efficacy, and cost-effective production. Despite their success, challenges remain for future development.