期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 91, 期 -, 页码 475-504出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-032620-110804
关键词
-
资金
- Jane Coffin Childs Memorial Fund for Medical Research
- Kwanjeong Educational Foundation
- Biocodex Microbiota Foundation
- National Science Foundation [CHE-20380529]
Enzymes in the DMSO reductase superfamily are diverse and can catalyze oxygen atom transformations efficiently and selectively under mild conditions. However, the applications and characterization of these enzymes are still underexplored.
Molybdenum- and tungsten-dependent proteins catalyze essential processes in living organisms and biogeochemical cycles. Among these enzymes, members of the dimethyl sulfoxide (DMSO) reductase superfamily are considered the most diverse, facilitating a wide range of chemical transformations that can be categorized as oxygen atom installation, removal, and transfer. Importantly, DMSO reductase enzymes provide high efficiency and excellent selectivity while operating under mild conditions without conventional oxidants such as oxygen or peroxides. Despite the potential utility of these enzymes as biocatalysts, such applications have not been fully explored. In addition, the vast majority of DMSO reductase enzymes still remain uncharacterized. In this review, we describe the reactivities, proposed mechanisms, and potential synthetic applications of selected enzymes in the DMSO reductase superfamily. We also highlight emerging opportunities to discover new chemical activity and current challenges in studying and engineering proteins in the DMSO reductase superfamily.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据