期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 91, 期 -, 页码 321-351出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-040320-104151
关键词
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资金
- Spanish Government [PID2019-104544GB-I00]
- Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
This article reviews the various types of nonspecific interactions between proteins and other macromolecules and supramolecular structures in the cellular interior, and summarizes the current state of knowledge and suggestions for future research.
The cellular interior is composed of a variety of microenvironments defined by distinct local compositions and composition-dependent intermolecular interactions. We review the various types of nonspecific interactions between proteins and between proteins and other macromolecules and supramolecular structures that influence the state of association and functional properties of a given protein existing within a particular microenvironment at a particular point in time. The present state of knowledge is summarized, and suggestions for fruitful directions of research are offered.
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