Extramedullary haematopoiesis in patients with transfusion dependent beta-thalassaemia (TDT): a systematic review

Letter Hematology

A novel index to evaluate ineffective erythropoiesis in hematological diseases offers insights into sickle cell disease

John Brewin et al.

HAEMATOLOGICA (2022)

Review Hematology

The spectrum of beta-thalassemia mutations in the 22 Arab countries: a systematic review

Aisha Moeen Khan et al.

Summary: The study investigated the mutational spectrum in the HBB gene among Arab patients with beta-thal. Consanguinity was high among these patients, and migration has led to allelic heterogeneity among Arab patients with beta-thal.

EXPERT REVIEW OF HEMATOLOGY (2021)

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Article Medicine, General & Internal

Achievement of Pre- and Post-Transfusion Hemoglobin Levels in Adult Transfusion-Dependent Beta Thalassemia: Associated Factors and Relationship to Reduction of Spleen Enlargement

Tubagus Djumhana Atmakusuma et al.

Summary: The achievement of pre-and post-transfusion hemoglobin levels in adult transfusion-dependent beta-thalassemia patients significantly reduced spleen enlargement and contributed to better patient outcomes. Researchers found that the amount of blood transfusion deficit and reaching the hemoglobin targets were related to spleen enlargement, while thalassemia genotype, blood compatibility, and transfusion interval were not correlated.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

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Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, General & Internal

Low back pain in beta thalassemia major revealing sacral extramedullay hematopoeisis: A case report

Rita W. Ahmad et al.

Summary: Extramedullary hematopoiesis is a common complication of beta thalassemia major, often seen in typical sites such as liver or spleen. However, when it occurs in unusual sites like the sacrum, other diagnoses should be ruled out through histopathology before determining the treatment plan.

CLINICAL CASE REPORTS (2021)

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Article Hematology

The association between pre-transfusion hemoglobin levels and thalassemia complications

Wasuwit Wanchaitanawong et al.

Summary: Lower Hb levels were associated with more frequent complications in both TDT and NTDT patients. Specific Hb cutoff values were identified for predicting these complications.

HEMATOLOGY (2021)

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Article Medicine, General & Internal

Spinal cord compression due to extramedullary hematopoiesis in patient with Beta thalassemia major

Eihab A. Subahi et al.

Summary: Extramedullary hematopoiesis can cause spinal cord compression in patients with beta thalassemia major, and radiotherapy can be effective in resolving neurological symptoms in such cases.

CLINICAL CASE REPORTS (2021)

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Review Biochemistry & Molecular Biology