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Review
Allergy
Bryan Oronsky et al.
Summary: Persistent post-COVID syndrome, a pathologic entity, involves persistent physical, medical, and cognitive sequelae following COVID-19. The syndrome includes immunosuppression and organ fibrosis, and its potential long-term effects place a burden on healthcare systems, patients' families, and society.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Clinical Neurology
Ana P. Boucas et al.
Summary: Severe COVID-19 patients exhibit an overreaction of the immune system, resulting in a cytokine storm and increased inflammation. This article discusses the potential risk of depression in survivors of severe COVID-19 who experience significant immune system activation. It also proposes the mechanisms of how cytokine storm and SARS-CoV-2 neuroinvasion may lead to long-term mental health consequences.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sedat Giray Kandemirli et al.
Summary: This study evaluated 23 patients with persistent COVID-19 olfactory dysfunction, finding olfactory cleft and olfactory bulb abnormalities to be common in cases of COVID-19 anosmia. The study also revealed a relatively high percentage of olfactory bulb degeneration, indicating a need for further longitudinal imaging studies to better understand the mechanism of olfactory neuronal pathway injury in COVID-19 anosmia.
ACADEMIC RADIOLOGY
(2021)
Article
Neurosciences
Amin Gasmi et al.
Summary: COVID-19, caused by the novel coronavirus SARS-CoV2, is a global pandemic with not only respiratory manifestations but also common CNS involvements. The mechanisms of neuroinvasion by SARS-CoV2 are still unclear.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Gabriel A. de Erausquin et al.
Summary: The impact of SARS-CoV-2 on the central nervous system has raised concerns about the risk of later life cognitive decline, Alzheimer's disease, and other dementia. An international consortium has been formed to study the short and long-term consequences of the virus on the CNS and enroll individuals for evaluations to better understand the underlying biology contributing to AD and dementia.
ALZHEIMERS & DEMENTIA
(2021)
Editorial Material
Gastroenterology & Hepatology
Max Schmulson et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Melanie Dani et al.
Summary: The COVID-19 pandemic has caused unprecedented morbidity, mortality, and disruption, with a new syndrome known as 'long COVID' emerging among survivors. This syndrome, characterized by debilitating symptoms like breathlessness and palpitations, may be related to autonomic nervous system disruption post-infection. Physicians should recognize and support individuals with 'long COVID' symptoms, with a focus on managing the underlying impaired autonomic physiology.
Review
Medical Laboratory Technology
Victoria Higgins et al.
Summary: COVID-19, caused by SARS-CoV-2, has resulted in over 57.8 million confirmed cases worldwide with potential long-term health consequences for recovered patients. While multi-organ manifestations are well-documented, the long-term implications remain to be fully uncovered, necessitating large cohort studies to better understand the breadth and severity of long-term effects.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2021)
Review
Psychiatry
Elizabeta B. Mukaetova-Ladinska et al.
Summary: The review discusses the neurobiological explanation for neurocognitive disorders caused by the COVID-19 pandemic, focusing on viral-induced inflammation, mechanisms of viral entry into the central nervous system, and altered neurotransmitter systems. The symptoms of mild and major neurocognitive disorders present an opportunity to study early changes underlying neurocognitive impairment at both clinical and molecular levels, and to explore management strategies and future therapeutic opportunities.
CURRENT OPINION IN PSYCHIATRY
(2021)
Review
Dermatology
Giovanni Genovese et al.
Summary: COVID-19 is a global pandemic caused by SARS-CoV-2, with common symptoms including fever, cough, fatigue, dyspnea, and hypogeusia/hyposmia. Dermatological manifestations have been increasingly reported, leading to a proposed classification of six main clinical patterns. This review summarizes the knowledge on these cutaneous manifestations, focusing on clinical features, therapeutic management, and hypothesized pathophysiological mechanisms.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Bai et al.
Summary: Quantitative analysis using [F-18] FDG PET/CT revealed significant inflammation remaining in the lungs, mediastinal lymph nodes, spleen, and liver in patients convalescing post severe COVID-19 infection, even after two consecutive negative RT-PCR tests.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Guedj et al.
Summary: In long COVID patients, brain PET scans showed significant hypometabolism in areas including bilateral rectal/orbital gyrus, temporal lobe, brainstem, and cerebellum. These metabolic abnormalities were associated with more functional complaints such as hyposmia/anosmia, memory/cognitive impairment, pain, and insomnia. The study suggests a potential biomarker value in identifying and monitoring long COVID patients, with implications for the impact of ACE drugs and nasal decongestant spray on brain metabolism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Gastroenterology & Hepatology
Yun Kit Yeoh et al.
Summary: This study found that the gut microbiome composition was significantly altered in patients with COVID-19 compared to non-COVID-19 individuals, regardless of medication received. Certain gut commensals known for their immunomodulatory potential were underrepresented in patients and remained low even after disease resolution. Additionally, the altered gut microbiome composition correlated with disease severity and elevated levels of inflammatory cytokines and blood markers.
Article
Immunology
Eric Song et al.
Summary: The study showed through three approaches that SARS-CoV-2 is capable of infecting brain neurons, leading to metabolic changes and pathological features without triggering type I interferon responses. These results provide evidence for the neuroinvasive capacity of SARS-CoV-2 and the unexpected consequence of direct infection of neurons by the virus.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Iraklis C. Moschonas et al.
Summary: The global COVID-19 pandemic has caused widespread infections and deaths, with thrombotic complications from infections involving various respiratory viruses having interconnected pathophysiological mechanisms. The incidence of thrombotic events in viral respiratory infections, including SARS-CoV-2, highlights the need for timely antithrombotic therapy and prophylaxis.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Editorial Material
Infectious Diseases
Devon E. McMahon et al.
LANCET INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Peter Wostyn
Summary: The concern of long-term sequelae resembling myalgic encephalomyelitis/chronic fatigue syndrome in COVID-19 patients has led to the need for clarifying mechanisms underlying post-COVID-19 fatigue syndrome. Integrating insights from various conditions, the study suggests a hypothesis involving damage to olfactory sensory neurons leading to congestion in the glymphatic system as a potential cause. Research is needed to confirm this hypothesis and explore the role of the glymphatic-lymphatic system in combating post-COVID-19 fatigue syndrome.
MEDICAL HYPOTHESES
(2021)
Review
Biochemistry & Molecular Biology
Deidiane Elisa Ribeiro et al.
Summary: Complications of COVID-19 may cause neuroinflammatory responses, triggering and exacerbating neurological disorders. Diseases associated with neuroimmune activation may increase susceptibility to SARS-CoV-2 infection and lead to severe conditions.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Christian Gaebler et al.
Summary: After infection with SARS-CoV-2, antibody levels against the spike protein decrease significantly, but the number of memory B cells remain unchanged, indicating an evolving humoral response at 6.2 months after infection.
Letter
Medicine, General & Internal
Daniel P. Perl et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Medicine, Research & Experimental
George B. Stefano et al.
Summary: Alterations in brain functioning due to SARS-CoV-2 infection and COVID-19 can result in long-term mental and cognitive changes, including symptoms like "brain fog". Hypoxia in certain brain areas may benefit the virus's reproductive capacity, causing dysfunction in neurons with high oxygen demand, leading to cognitive impairment and behaviors that favor viral spread.
MEDICAL SCIENCE MONITOR
(2021)
Article
Physiology
Justina Motiejunaite et al.
Summary: As the COVID-19 pandemic enters its second phase, the focus must shift towards post-acute care for survivors, many of whom continue to experience persistent cardiorespiratory symptoms months after the initial infection. The pathophysiology of exercise intolerance in these individuals remains poorly understood, necessitating further research to investigate potential mechanisms.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Critical Care Medicine
Ranju T. Dhawan et al.
Summary: COVID-19 is associated with pulmonary thrombosis and thromboembolism, potentially leading to pulmonary fibrotic damage and long-term consequences. A proactive follow-up strategy is needed to evaluate residual clot burden, small vessel injury, and potential hemodynamic sequelae. A nuanced and physiological approach to follow-up imaging is crucial for informing therapeutic strategies in case of clinically significant pulmonary vascular sequelae.
LANCET RESPIRATORY MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shin Jie Yong
Summary: Long-COVID is a postviral illness that can affect survivors of COVID-19, potentially caused by long-term tissue damage, viral persistence, and dysfunction of the brainstem. The brainstem plays a crucial role in manifesting symptoms, including respiratory, cardiovascular, and neurological functions, thus potentially linking it to long-COVID.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Dermatology
Surabhi Sharma et al.
Summary: Recent reports have described a variety of cutaneous signs associated with COVID-19, with some cases showing only skin manifestations rather than typical symptoms. There is significant heterogeneity amongst the described cutaneous signs, requiring further investigation.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2021)
Article
Immunology
Juanjuan Xu et al.
Summary: This study aimed to analyze the plasma metabolomic profile of COVID-19 survivors with pulmonary sequelae, revealing differences in metabolite profiles between patients with abnormal pulmonary function and healthy donors, primarily involving amino acid and glycerophospholipid metabolic pathways. Results showed that plasma metabolite profiles were associated with disease severity and could be used to identify COVID-19 survivors with abnormal pulmonary function.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Viviana Versace et al.
Summary: The study revealed reduced GABAergic inhibition in the primary motor cortex of patients who recovered from COVID-19 with neurological complications, presenting fatigue and executive function syndrome. TMS may serve as a diagnostic tool for assessing cognitive disturbances and fatigue in post-COVID-19 patients.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini et al.
Summary: The study hypothesized that whole-body [18F]FDG-PET/CT could provide insight into the pathophysiology of long COVID. Results revealed increased [18F]FDG uptake in various organs of long COVID patients, suggesting underlying systemic inflammation. Brain hypometabolism patterns were associated with persistent symptoms, indicating different temporal sequences of brain and whole-body inflammatory changes. Whole-body [18F]FDG PET was found to hold potential value in disclosing the pathophysiology of long COVID.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Ophthalmology
Maria Cristina Savastano et al.
Summary: Macula and perimacular vessel density and perfusion were found to be unaltered in mild post-COVID-19 patients at 1-month hospital discharge, indicating minimal or no retinal vascular involvement by SARS-CoV-2.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Medicine, Research & Experimental
Krishna P. Murthy et al.
Summary: The COVID-19 pandemic has caused a global public health emergency with millions affected worldwide. Global efforts are being made by scientists to combat the virus with the development of treatments, and the World Health Organization provides updates on treatment progress.
Article
Biochemistry & Molecular Biology
Carole H. Sudre et al.
Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.
Review
Physiology
Marie-Benedicte Le Stang et al.
Summary: Kidney involvement during COVID-19 may result from a combination of factors including direct viral targeting, local inflammation, and hemodynamic alterations, although direct viral infection has not been confirmed in kidney biopsies so far.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Bing Sun et al.
Summary: A study showed increased levels of plasma cytokines and nEV proteins in individuals recovering from COVID-19, potentially leading to neuronal dysfunction, especially in patients with neurological issues and those recovering from the infection. Longitudinal studies are needed to monitor these biomarkers to assess neural damage and systemic effects.
Article
Immunology
Aditi Ramakrishnan et al.
Summary: This study reviewed 127 encounters of PCR-confirmed COVID-19 cases at a multidisciplinary outpatient clinic, finding that patients can experience persistent respiratory symptoms that may require hospitalization.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Ashraf Roshdy et al.
Summary: Analysis of cardiac tissue autopsy findings in COVID-19 decedents revealed common cardiac pathologies such as cardiac dilation, ischemia, and myocarditis. A minority of cases showed infiltration of SARS-CoV-2 into the myocardium. Standardization of cardiac postmortem protocols is needed for further research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Rheumatology
Sakir Ahmed et al.
Summary: COVID-19 can lead to various autoimmune disorders, post-COVID-19 syndromes, and multi-system inflammatory syndrome. The infection of SARS-CoV-2 may cause endotheliitis and thrombosis, activate immune systems, and result in the formation of autoantibodies. It is important to monitor recovery patients for autoimmune manifestations and production of autoantibodies in the context of rheumatic diseases.
CLINICAL RHEUMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuanyuan Qin et al.
Summary: The study found that COVID-19 patients showed severe changes in gray matter, white matter, and cerebral blood flow, especially in patients with severe disease. These changes were significantly correlated with inflammatory markers, suggesting that the inflammatory storm may cause indirect brain damage.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Infectious Diseases
Eleni Korompoki et al.
Summary: Long COVID, characterized by persistent or new symptoms in COVID-19 survivors, can involve all body systems and have a negative impact on mental health and quality of life. Despite unclear pathogenesis, early recognition and thorough follow-up are essential for holistic treatment of survivors.
JOURNAL OF INFECTION
(2021)
Article
Clinical Neurology
A. L. Ren et al.
Summary: COVID-19 is primarily a respiratory disease, but can also lead to neurological complications. The main processes causing neurological damage include cerebrovascular disease, immunologically mediated neurological disorders, and the harmful effects of critical illness on the nervous system. While it is still uncertain if the virus directly invades the nervous system, the large number of infections at present suggests that nervous system infection may not be a significant issue.
JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ganna Blazhenets et al.
Summary: Cognitive impairment in COVID-19 patients can be related to cortical hypometabolism, which shows reversibility after 6 months. Despite significant recovery, residual impairments remain in some patients.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
John J. L. Jacobs
Summary: COVID-19 is a serious disease that has infected more than 40 million people, with long COVID possibly being caused by persistent systemic infection.
MEDICAL HYPOTHESES
(2021)
Article
Multidisciplinary Sciences
Eric Y. Wang et al.
Summary: COVID-19 patients show increased autoantibody reactivities against immunomodulatory proteins, which may affect immune function and lead to different clinical outcomes.
Review
Biochemistry & Molecular Biology
Ani Nalbandian et al.
Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.
Review
Endocrinology & Metabolism
Pierpaolo Trimboli et al.
Summary: This systematic review provides insights into potential thyroid consequences in COVID-19 patients, including thyrotoxicosis, low-T3 syndrome, and subacute thyroiditis. It concludes that having a thyroid disease does not increase the risk of SARS-CoV-2 infection, and that thyroid patients do not require a specific COVID-19-adapted follow-up. However, factors like critical illness and medication may affect thyroid laboratory tests.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Cell Biology
Guilherme Dias de Melo et al.
Summary: Recent investigations have shown that olfactory and taste dysfunction are common in mildly symptomatic COVID-19 patients. Research on the olfactory neuroepithelium revealed that SARS-CoV-2 infection can cause local inflammation and lead to acute loss of smell, which may account for prolonged symptoms of COVID-19 such as anosmia.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Virology
Bruno Silva Andrade et al.
Summary: The global COVID-19 pandemic has led to millions of infections, creating a long-term care burden for survivors. It is crucial to study both short-term and long-term effects, as they impact various human systems.
Article
Biology
Florence W. J. Chioh et al.
Summary: The impact of COVID-19 on vascular health of recovered patients is significant, with elevated levels of circulating endothelial cells indicating vascular injury. The presence of proinflammatory and activated T lymphocyte-associated cytokines suggests cytokine-driven endothelial dysfunction. Effector T cells were more frequent in COVID-19 convalescents, pointing to a possible cytotoxic effector cell targeting of activated endothelial cells.
Article
Critical Care Medicine
Woo-Jung Song et al.
Summary: Cough is a common symptom of COVID-19 and can persist for weeks or even months after infection, leading to long-term effects known as post-COVID syndrome. Researchers hypothesize that neurotropic pathways may be responsible for cough hypersensitivity state after SARS-CoV-2 infection, and neuroinflammatory events in the brain could contribute to the development of post-COVID syndrome. There are gaps in understanding the mechanisms of acute and chronic COVID-19 associated cough and post-COVID syndrome, but potential ways to reduce the impact of COVID-19 by controlling cough are being considered.
LANCET RESPIRATORY MEDICINE
(2021)
Review
Respiratory System
Suzana Erico Tanni et al.
Summary: There is limited understanding of the risk factors, histopathology, and pathophysiology of post-COVID-19 pulmonary fibrosis. Serial clinical screening for pulmonary fibrosis is recommended after COVID-19, and further research is needed to determine the risk factors and appropriate management of post-COVID-19 pulmonary fibrosis.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Article
Pathology
Maire E. Doyle et al.
Summary: The study found that SARS-CoV-2 may enter the human body through infecting taste papillae cells, affecting taste receptor stem cell activity and causing taste impairment. Some patients still had not fully recovered, with disrupted taste stem cells.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Immunology
Alberto Perez-Gomez et al.
Summary: SARS-CoV-2 infection causes abnormal immune response, affecting the quantity and function of dendritic cells, with some markers remaining altered during acute phase and follow-up.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Alex G. Richter et al.
Summary: The study revealed a higher frequency of autoantibodies associated with SARS-CoV-2 infection in COVID-19 patients, even detectable months post-infection. COVID-19 patients displayed a more restricted pattern of autoantibodies, including skin, skeletal muscle, and cardiac antibodies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Javier Garcia-Abellan et al.
Summary: Long-COVID is associated with weak anti-SARS-CoV-2 antibody response, severity of illness, and female gender. Late clinical events and persistent symptoms in the medium and long term occur in a significant proportion of patients hospitalized for COVID-19.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
John M. Arthur et al.
Summary: Many patients with a history of SARS-CoV-2 infection have developed specific antibodies against ACE2, which may decrease the activity of soluble ACE2 in plasma and increase levels of Ang II, potentially triggering symptoms of PASC.
Review
Medicine, General & Internal
Harry Crook et al.
Summary: The long-term effects of covid-19 can affect multiple systems in the body, leading to persistent symptoms that impact patients of varying severity. These symptoms include fatigue, dyspnea, and cognitive impairment, among others. Studies discuss risk factors for acute and long covid, as well as potential therapeutic options.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Infectious Diseases
Shin Jie Yong
Summary: Long COVID or post-COVID-19 syndrome is a poorly understood condition that affects survivors with symptoms like fatigue, dyspnoea, cognitive impairments, and more. The pathophysiology, risk factors, and treatments are still lacking in literature, but potential treatments may include rehabilitation training and repurposed drugs from similar conditions. Further research is needed to substantiate risk factors and treatment options.
INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Hyung J. Chun et al.
Summary: This study found that biological factors related to neutrophil activation, fibrosis signaling, and alveolar repair may be novel therapeutic or prognostic targets for individuals recovering from COVID-19 with persistent respiratory symptoms.
Review
Neurosciences
Nadine Attal et al.
Summary: COVID-19 commonly presents with respiratory symptoms, but pain is also a common symptom, some of which may be neuropathic. Various viral infections like herpes zoster and HIV can cause neurological complications including neuropathic pain, and COVID-19 can also lead to neurological complications that may result in chronic neuropathic pain. Longitudinal cohort studies are needed to evaluate the exact risk of neuropathic pain after COVID-19.
Article
Medicine, Research & Experimental
Leonard A. Jason et al.
Summary: Symptoms among long-hauler COVID-19 patients tend to decrease over time, with an intensification of neurocognitive symptoms, while compared to ME/CFS, COVID-19 long-haulers initially have more severe symptoms in immune and orthostatic domains but show less severe symptoms over time, except in the orthostatic domain.
FATIGUE-BIOMEDICINE HEALTH AND BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Halima A. Shuwa et al.
Summary: The study describes the phenotypic and functional characteristics of B and T cells in hospitalized COVID-19 patients during acute disease and at 3-6 months of convalescence. The alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients, while T cells from convalescent patients displayed continued alterations. Different subgroups of convalescent patients were identified based on distinct lymphocyte phenotypes, with one subgroup associated with poorer clinical outcomes.
Review
Medicine, General & Internal
Timothy L. Wong et al.
Summary: Early studies on long COVID symptoms show significant overlaps with ME/CFS, highlighting the need for monitoring and treatment. Further research into the similarities and differences between long COVID and ME/CFS is warranted.
MEDICINA-LITHUANIA
(2021)
Article
Immunology
Gerd Wallukat et al.
Summary: Within a sample of long-term COVID-19 recovered patients, various GPCR-fAABs autoantibodies were detected, with some antibodies causing positive chronotropic effects on cardiac cells while affecting the nervous and cardiovascular systems significantly.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2021)
Article
Psychology, Multidisciplinary
Sanjay Kumar et al.
Summary: COVID-19 may have long-term mental health effects on patients, necessitating global recognition and planning to address mental health issues. Research indicates that patients may develop neurological symptoms and the virus could potentially cause damage to the nervous system, leading to long-term neuropsychiatric sequelae.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Betty Raman et al.
Summary: The study found that COVID-19 patients discharged from the hospital still experience breathlessness, fatigue, cognitive impairment, and mental health issues. MRI revealed abnormalities in multiple organs, which were linked to inflammation and severity of acute illness.
Letter
Neurosciences
Francesco Benedetti et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini et al.
Summary: The study included 10 COVID-19 recovered patients with persistent symptoms, showing increased [F-18]FDG uptake in bone marrow and blood vessels. Compared to controls, the recovered patients had higher [F-18]FDG uptake ratios, indicating that SARS-CoV-2 may induce vascular inflammation leading to persisting symptoms.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Oliver O'Sullivan
Summary: Both survivors of SARS and MERS faced chronic problems, which could provide insights for the medical planning for survivors of COVID-19, particularly focusing on cardiopulmonary sequelae, fatigue, and psychological burden.
Review
Physiology
Leif Ostergaard
Summary: COVID-19 infection can cause symptoms in multiple organs, including low blood oxygen levels, muscle pain, fatigue, and mood changes. Capillary damage and inflammation may play a role in these symptoms.
PHYSIOLOGICAL REPORTS
(2021)
Article
Medicine, General & Internal
Andrea Dennis et al.
Summary: A study conducted in two UK community centers found that 70% of individuals with persistent symptoms following recovery from SARS-CoV-2 infection had impairment in one or more organs 4 months after initial COVID-19 symptoms. Common symptoms included fatigue, muscle aches, breathlessness, and headaches.
Letter
Immunology
Si Su et al.
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Review
Immunology
Emily A. Troyer et al.
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Clinical Neurology
Hayrunnisa Bolay et al.
Letter
Medicine, General & Internal
Tina Schaller et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Orthopedics
Nathaniel P. Disser et al.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2020)
Letter
Medicine, General & Internal
Zsuzsanna Varga et al.
Article
Medicine, General & Internal
Maximilian Ackermann et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Letter
Endocrinology & Metabolism
Sandro Gentile et al.
DIABETES OBESITY & METABOLISM
(2020)
Review
Cardiac & Cardiovascular Systems
Raul D. Mitrani et al.
Review
Cardiac & Cardiovascular Systems
Paul C. Evans et al.
CARDIOVASCULAR RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Diana Lindner et al.
Review
Immunology
Souhel Najjar et al.
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Pathology
Simona De Michele et al.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2020)
Article
Infectious Diseases
Luca Carsana et al.
LANCET INFECTIOUS DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Camila Rosat Consiglio et al.
Review
Biochemistry & Molecular Biology
Costantino Iadecola et al.
Article
Biochemistry & Molecular Biology
Quan-Xin Long et al.
Editorial Material
Rheumatology
Caroline Galeotti et al.
NATURE REVIEWS RHEUMATOLOGY
(2020)
Editorial Material
Clinical Neurology
Michael T. Heneka et al.
ALZHEIMERS RESEARCH & THERAPY
(2020)
Editorial Material
Medicine, General & Internal
Trisha Greenhalgh et al.
BMJ-BRITISH MEDICAL JOURNAL
(2020)
Review
Neurosciences
Sayed Ausim Azizi et al.
JOURNAL OF NEUROVIROLOGY
(2020)
Article
Nutrition & Dietetics
Alex Pizzini et al.
Review
Pediatrics
Danilo Buonsenso et al.
FRONTIERS IN PEDIATRICS
(2020)
Review
Cardiac & Cardiovascular Systems
Kirsty A. Roberts et al.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Editorial Material
Biochemistry & Molecular Biology
Abdul Mannan Baig
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Neurosciences
Thorsten Rudroff et al.
Article
Biochemistry & Molecular Biology
Gaetano Pietro Bulfamante et al.
Article
Respiratory System
Thomas Sonnweber et al.
RESPIRATORY RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Itsuro Kazama
DRUG DISCOVERIES AND THERAPEUTICS
(2020)
Article
Infectious Diseases
Lawrence B. Afrin et al.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Medicine, Research & Experimental
Mohammed F. Islam et al.
FATIGUE-BIOMEDICINE HEALTH AND BEHAVIOR
(2020)
Review
Respiratory System
Ademola S. Ojo et al.
PULMONARY MEDICINE
(2020)
Article
Medicine, General & Internal
Yiping Lu et al.
Review
Psychiatry
Luca Steardo et al.
TRANSLATIONAL PSYCHIATRY
(2020)
Review
Immunology
Michael Ogier et al.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2020)
Review
Immunology
T. Y. M. Leung et al.
EMERGING MICROBES & INFECTIONS
(2020)
