4.5 Article

Real-world experience of anti-D immunoglobulin in immune thrombocytopenia

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ANNALS OF HEMATOLOGY
卷 101, 期 6, 页码 1173-1179

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SPRINGER
DOI: 10.1007/s00277-022-04829-4

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Anti-D; Immune thrombocytopenia; ITP; Resource constraint settings; Thrombocytopenia; Immunoglobulin

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This retrospective study analyzed the response and safety profile of using anti-D in patients with severe immune thrombocytopenia (ITP) in developing countries. The results showed that anti-D treatment significantly increased platelet counts and had a good response rate in different phases and populations of ITP, with a good safety profile.
In developing countries, anti-D has been used in immune thrombocytopenia (ITP) as a cheaper alternative to human immunoglobulin. We aim to analyze the response and safety profile of anti-D in patients with severe ITP. A retrospective study was conducted at a tertiary care hospital in Northern India. Patients received a single intravenous infusion of 75 mu g/kg anti-D. In total, 36 patients (20 females) were included in this study. The median duration from ITP diagnosis to anti-D therapy was 235 days (range 1-1613 days). Four (11.1%) patients received anti-D as an upfront treatment. The patients' platelet counts rose significantly by the end of day three and continued to be significantly high until day 30 of receiving anti-D (p <= 0.001). The overall response rate (ORR) by day seven was 88.89%. There was no effect of age, sex, duration of disease, prior therapy, and platelet count on the ORR. Patients were followed up for a median duration of 52 days (longest follow-up: 3080 days). Six (6/36, 16.67%) patients continued to be in remission till the last follow-up. The hemoglobin fall was statistically significant on day three and day seven (p < 0.001 and p = 0.001) and got normalized by day 30. We observed equally good ORR in mixed populations and different phases of ITP along with long-term sustained response. The study demonstrates a quick and high response rate along with good safety profile to anti-D in all forms of ITP.

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