4.5 Letter

Hepatitis B reactivation during ruxolitinib treatment

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Article Hematology

Risk of hepatitis B virus reactivation following ruxolitinib treatment in patients with myeloproliferative neoplasms

Ming-Hui Duan et al.

Summary: This retrospective analysis aimed to evaluate the incidence of hepatitis B virus (HBV) reactivation among myeloproliferative neoplasms (MPN) patients treated with ruxolitinib. The study found that patients with chronic HBV infection who did not receive antiviral prophylaxis may commonly experience HBV reactivation and hepatitis flare after a few months of ruxolitinib treatment, especially when combined with TSP. In contrast, HBV reactivation was extremely rare in patients with resolved HBV infection.

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