Characterizing Musculoskeletal Tissue Mechanics Based on Shear Wave Propagation: A Systematic Review of Current Methods and Reported Measurements

Developing methods for the non-invasive characterization of the mechanics of musculoskeletal tissues is an ongoing research focus in biomechanics. Often, these methods use the speed of shear wave propagation to characterize tissue mechanics (e.g., shear wave elastography and shear wave tensiometry). The primary purpose of this systematic review was to identify, compare, and contrast current methods for exciting and measuring shear wave propagation in musculoskeletal tissues. We conducted searches in the Web of Science, PubMed, and Scopus databases for studies published from January 1, 1900, to May 1, 2020. These searches targeted both shear wave excitation using acoustic pushes and mechanical taps, and shear wave speed measurement using ultrasound, magnetic resonance imaging, accelerometers, and laser Doppler vibrometers. Two reviewers independently screened and reviewed the articles, identifying 524 articles that met our search criteria. Regarding shear wave excitation, we found that acoustic pushes are useful for exciting shear waves through the thickness of the tissue of interest, and mechanical taps are useful for exciting shear waves in wearable applications. Regarding shear wave speed measurement, we found that ultrasound is used most broadly to measure shear waves due to its ability to study regional differences and target specific tissues of interest. The strengths of magnetic resonance imaging, accelerometers, and laser Doppler vibrometers make them advantageous to measure shear wave speeds for high-resolution shear wave imaging, wearable measurements, and non-contact ex vivo measurements, respectively. The advantages that each method offers for exciting and measuring shear waves indicate that a variety of systems can be assembled using currently available technologies to determine musculoskeletal tissue material behavior across a range of innovative applications.

Automated summary

This systematic review focuses on the methods used to excite and measure shear wave propagation in musculoskeletal tissues. The review identifies various techniques, including acoustic pushes, mechanical taps, ultrasound, magnetic resonance imaging, accelerometers, and laser Doppler vibrometers. Each method has its advantages and can be used to determine material behavior in different applications.