相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Class I histone deacetylases (HDAC1-3) are histone lysine delactylases
Carlos Moreno-Yruela et al.
SCIENCE ADVANCES (2022)
Genetically Encoded Benzoyllysines Serve as Versatile Probes for Interrogating Histone Benzoylation and Interactions in Living Cells
Hongtao Tian et al.
ACS CHEMICAL BIOLOGY (2021)
Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins
Xiangle Ren et al.
NUCLEIC ACIDS RESEARCH (2021)
Live-cell epigenome manipulation by synthetic histone acetylation catalyst system
Yusuke Fujiwara et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Targeted Protein Acetylation in Cells Using Heterobifunctional Molecules
Wesley W. Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription
Lara Zorro Shahidian et al.
EMBO REPORTS (2021)
Single-step fluorescent probes to detect decrotonylation activity of HDACs through intramolecular reactions
Yusheng Xie et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway
He Huang et al.
SCIENCE ADVANCES (2021)
A tri-functional amino acid enables mapping of binding sites for posttranslational-modification-mediated protein-protein interactions
Jianwei Lin et al.
MOLECULAR CELL (2021)
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
Yuhan Jiang et al.
NATURE COMMUNICATIONS (2021)
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
George M. Burslem et al.
CELL (2020)
Click Chemistry in Proteomic Investigations
Christopher G. Parker et al.
CELL (2020)
Photo Cross-Linking Probes Containing ε-N-Thioacyllysine and ε-N-Acyl-(δ-aza)lysine Residues
Michael Baek et al.
CHEMISTRY-A EUROPEAN JOURNAL (2020)
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors
Yaxi Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle
Tatsiana Kosciuk et al.
NATURE COMMUNICATIONS (2020)
Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase
Ka Yang et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
Peter S. J. Bailey et al.
NATURE COMMUNICATIONS (2020)
Desuccinylation-Triggered Peptide Self-Assembly: Live Cell Imaging of SIRT5 Activity and Mitochondrial Activity Modulation
Liu Yang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs
Yufeng Xiao et al.
CHEMICAL COMMUNICATIONS (2020)
The Chemical Biology of Reversible Lysine Post-translational Modifications
Zhipeng A. Wang et al.
CELL CHEMICAL BIOLOGY (2020)
Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling
Jian Guo et al.
CIRCULATION RESEARCH (2019)
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
Helai P. Mohammad et al.
NATURE MEDICINE (2019)
Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans
Min Ni et al.
CELL REPORTS (2019)
Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells
Xin Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Xiaoyu Zhang et al.
NATURE CHEMICAL BIOLOGY (2019)
Molecular basis for hierarchical histone de-β-hydroxybutmlation by SIRT3
Xingrun Zhang et al.
CELL DISCOVERY (2019)
SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration
Nicole A. Spiegelman et al.
ACS CHEMICAL BIOLOGY (2019)
Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics
Xiucong Bao et al.
MOLECULAR CELL (2019)
Chemical Tools with Fluorescence Switches for Verifying Epigenetic Modifications
Yuichiro Hori et al.
ACCOUNTS OF CHEMICAL RESEARCH (2019)
Chemical Probes Reveal Sirt2's New Function as a Robust Eraser of Lysine Lipoylation
Yusheng Xie et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Metabolic regulation of gene expression by histone lactylation
Di Zhang et al.
NATURE (2019)
Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation
Matthias Schiedel et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains
Melissa D'Ascenzio et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53
John Hines et al.
CANCER RESEARCH (2019)
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7
Wesley Wei Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)
Matthias Schiedel et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Development of Activity-Based Chemical Probes for Human Sirtuins
Elysian Graham et al.
ACS CHEMICAL BIOLOGY (2018)
Histone Deacetylase 11 Is a Fatty-Acid Deacylase
Zsofia Kutil et al.
ACS CHEMICAL BIOLOGY (2018)
Chemical and Biochemical Perspectives of Protein Lysine Methylation
Minkui Luo
CHEMICAL REVIEWS (2018)
Small molecules as tools to study the chemical epigenetics of lysine acetylation
Matthias Schiedel et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2018)
A Chemical Probe for Protein Crotonylation
Jeffrey Bos et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action
Shridhar Bhat et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis
He Huang et al.
MOLECULAR CELL (2018)
Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation
Yi Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases
Rachel Fellows et al.
NATURE COMMUNICATIONS (2018)
An Efficient Approach for Selective Enrichment of Histone Modification Readers Using Self-Assembled Multivalent Photoaffinity Peptide Probes
Guijin Zhai et al.
ANALYTICAL CHEMISTRY (2018)
A chemical reporter facilitates the detection and identification of lysine HMGylation on histones
Xiucong Bao et al.
CHEMICAL SCIENCE (2018)
Lysine benzoylation is a histone mark regulated by SIRT2
He Huang et al.
NATURE COMMUNICATIONS (2018)
Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking
Xin Li et al.
NATURE CHEMICAL BIOLOGY (2018)
Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway
He Huang et al.
CELL RESEARCH (2018)
Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase
Carlos Moreno-Yruela et al.
CELL CHEMICAL BIOLOGY (2018)
Chemical Biology Approaches for Investigating the Functions of Lysine Acetyltransferases
Maomao He et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
SIRT7 Is an RNA-Activated Protein Lysine Deacylase
Zhen Tong et al.
ACS CHEMICAL BIOLOGY (2017)
A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation
Zhipeng A. Wang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Metabolic regulation of gene expression through histone acylations
Benjamin R. Sabari et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Genetically Encoded Fluorescent Probe for Detecting Sirtuins in Living Cells
Weimin Xuan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking
Jeffrey E. Lopez et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Genetically Encoded Photoaffinity Histone Marks
Xiao Xie et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
Loren M. Lasko et al.
NATURE (2017)
KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase
Yugang Wang et al.
NATURE (2017)
Click chemistry enables preclinical evaluation of targeted epigenetic therapies
Dean S. Tyler et al.
SCIENCE (2017)
Dynamic Protein Acylation: New Suostrates, Vechanisms, and Drug Targets
Thomas Lanyon-Hogg et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
Min Liu et al.
NATURE COMMUNICATIONS (2017)
SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a
Hui Jing et al.
ELIFE (2017)
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
Xiaoyu Zhang et al.
ELIFE (2017)
Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight
Nima Rajabi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
Liron Bar-Peled et al.
CELL (2017)
A Suite of Minimalist Photo-Crosslinkers for Live-Cell Imaging and Chemical Proteomics: Case Study with BRD4 Inhibitors
Sijun Pan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Global profiling of crotonylation on non-histone proteins
Weizhi Xu et al.
CELL RESEARCH (2017)
Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription
Wei Wei et al.
CELL RESEARCH (2017)
Profiling Cellular Substrates of Lysine Acetyltransferases GCN5 and p300 with Orthogonal Labeling and Click Chemistry
Zhen Han et al.
ACS CHEMICAL BIOLOGY (2017)
A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation
Gregory R. Wagner et al.
CELL METABOLISM (2017)
A chemical probe toolbox for dissecting the cancer epigenome
Jake Shortt et al.
NATURE REVIEWS CANCER (2017)
Ligand and Target Discovery by Fragment-Based Screening in Human Cells
Christopher G. Parker et al.
CELL (2017)
Photo-lysine captures proteins that bind lysine post-translational modifications
Tangpo Yang et al.
NATURE CHEMICAL BIOLOGY (2016)
HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine
Pornpun Aramsangtienchai et al.
ACS CHEMICAL BIOLOGY (2016)
SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context
Zhen Tong et al.
ACS CHEMICAL BIOLOGY (2016)
A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes
Wesley Wei Wang et al.
ACS CHEMICAL BIOLOGY (2016)
The Substrate Specificity of Sirtuins
Poonam Bheda et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity
Hui Jing et al.
CANCER CELL (2016)
YEATS2 is a selective histone crotonylation reader
Dan Zhao et al.
CELL RESEARCH (2016)
Proteomic analysis of fatty-acylated proteins
Tao Peng et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2016)
Global Profiling of Acetyltransferase Feedback Regulation
David C. Montgomery et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases
Yusheng Xie et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones
Jing Jin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Supramolecular Affinity Labeling of Histone Peptides Containing Trimethyllysine and Its Application to Histone Deacetylase Assays
Isaiah N. Gober et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Yuanyuan Li et al.
MOLECULAR CELL (2016)
Proteome-wide covalent ligand discovery in native biological systems
Keriann M. Backus et al.
NATURE (2016)
Insights into newly discovered marks and readers of epigenetic information
Forest H. Andrews et al.
NATURE CHEMICAL BIOLOGY (2016)
Selective recognition of Histone crotonylation by double PHD fingers of MOZ and DPF2
Xiaozhe Xiong et al.
NATURE CHEMICAL BIOLOGY (2016)
The Taf14 YEATS domain is a reader of histone crotonylation
Forest H. Andrews et al.
NATURE CHEMICAL BIOLOGY (2016)
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
Kanak Raina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
Lei Li et al.
NATURE COMMUNICATIONS (2016)
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
Michael Zengerle et al.
ACS CHEMICAL BIOLOGY (2015)
Novel thiourea-based sirtuin inhibitory warheads
Wenwen Zang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Quantitative Proteomic Analysis of Histone Modifications
He Huang et al.
CHEMICAL REVIEWS (2015)
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
Jing Lu et al.
CHEMISTRY & BIOLOGY (2015)
Chemical methods for the proteome-wide identification of posttranslationally modified proteins
Kelly N. Chuh et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2015)
Chemical proteomics approaches to examine novel histone posttranslational modifications
Xin Li et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2015)
Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation
Benjamin R. Sabari et al.
MOLECULAR CELL (2015)
Phthalimide conjugation as a strategy for in vivo target protein degradation
Georg E. Winter et al.
SCIENCE (2015)
Real-time detection of histone deacetylase activity with a small molecule fluorescent and spectrophotometric probe
Debra R. Rooker et al.
CHEMICAL SCIENCE (2015)
Developing diazirine-based chemical probes to identify histone modification 'readers' and 'erasers'
Tangpo Yang et al.
CHEMICAL SCIENCE (2015)
Integrative Chemical Biology Approaches for Identification and Characterization of Erasers for Fatty-Acid-Acylated Lysine Residues within Proteins
Zheng Liu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity
Rommel A. Mathias et al.
CELL (2014)
Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5
Minjia Tan et al.
CELL METABOLISM (2014)
Minimalist Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling
Zhengqiu Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Stable Histone Adduction by 4-Oxo-2-nonenal: A Potential Link between Oxidative Stress and Epigenetics
James J. Galligan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems
Simona G. Codreanu et al.
MOLECULAR & CELLULAR PROTEOMICS (2014)
Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors
Bin He et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach
Xiucong Bao et al.
ELIFE (2014)
Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling
Zhengqiu Li et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
Jessica L. Feldman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
Hong Jiang et al.
NATURE (2013)
Azalysine Analogues as Probes for Protein Lysine Deacetylation and Demethylation
Blair C. R. Dancy et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Thiosuccinyl Peptides as Sirt5-Specific Inhibitors
Bin He et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Development of a Fluorogenic Probe with a Transesterification Switch for Detection of Histone Deacetylase Activity
Reisuke Baba et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Mechanism-based affinity capture of sirtuins
Yana Cen et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2011)
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Jintang Du et al.
SCIENCE (2011)
Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters
Guillaume Charron et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Structural insights into intermediate steps in the Sir2 deacetylation reaction
William F. Hawse et al.
STRUCTURE (2008)
Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide
Brian C. Smith et al.
BIOCHEMISTRY (2007)
A selective chemical probe for coenzyme A - Requiring enzymes
Yousang Hwang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Nε-thioacetyl-lysine:: A multi-facet functional probe for enzymatic protein lysine Nε-deacetylation
David G. Fatkins et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)