期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 27, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202202409
关键词
Antitumor Agents; Bacteria; Immunotherapy; Nanoactivators; Tumor Microenvironment
资金
- National Key Research and Development Program of China [SQ2021YFA090162]
- National Natural Science Foundation of China [21875135, 82104073]
- Innovative Research Team of High-Level Local Universities in Shanghai
- China Postdoctoral Science Foundation [BX20200216, 2021M692128]
This study reports a method of decorating bacteria with triple immune nanoactivators to develop tumor-resident living immunotherapeutics. The decorated bacteria show targeted tumor retention and release of drugs, achieving potent antitumor effects. This work provides a versatile platform for cancer immunotherapy.
An approach of decorating bacteria with triple immune nanoactivators is reported to develop tumor-resident living immunotherapeutics. Under cytocompatible conditions, tumor-specific antigens and checkpoint blocking antibodies are simultaneously conjugated onto bacterial surface and then polydopamine nanoparticles are formed via in situ dopamine polymerization. In addition to serving as a linker, polydopamine with its photothermal effect can repolarize tumor-associated macrophages to a pro-inflammatory phenotype. The linked antigens promote the maturation of dendritic cells and generate tumor-specific immune responses, while the anchored antibodies block immune checkpoints and activate cytotoxic T lymphocytes. Decorated bacteria show spatiotemporal tumor retention and proliferation-dependent drug release, achieving potent antitumor effects in two antigen-overexpressing tumor models. This work provides a versatile platform to prepare multimodal and long-acting therapeutics for cancer immunotherapy.
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