期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 24, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202116108
关键词
3D Printing; C-C Coupling; Chemical Education; Reactionware; Unit Operations
资金
- EPSRC [EP/L023652/1, EP/R020914/1, EP/S030603/1, EP/R01308X/1, EP/S017046/1, EP/S019472/1]
- ERC [670467 SMART-POM]
- EC [766975 MADONNA]
- John Templeton Foundation [60625, 61184]
- DARPA [W911NF-18-2-0036, W911NF-17-1-0316, HR001119S0003]
- NIH [GM118185]
- NSF [CHE2019897]
Chemistry digitization requires a standardized approach to link experiments with the code used to generate experimental conditions and outcomes. This study presents a new approach that combines process chemistry principles with 3D printed reactionware to digitize organic synthesis.
Chemistry digitization requires an unambiguous link between experiments and the code used to generate the experimental conditions and outcomes, yet this process is not standardized, limiting the portability of any chemical code. What is needed is a universal approach to aid this process using a well-defined standard that is composed of syntheses that are employed in modular hardware. Herein we present a new approach to the digitization of organic synthesis that combines process chemistry principles with 3D printed reactionware. This approach outlines the process for transforming unit operations into digitized hardware and well-defined instructions that ensure effective synthesis. To demonstrate this, we outline the process for digitizing 3 MIDA boronate building blocks, an ester hydrolysis, a Wittig olefination, a Suzuki-Miyaura coupling reaction, and synthesis of the drug sulfanilamide.
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