Circular Dichroism Based Chirality Sensing with Supramolecular Host-Guest Chemistry

Optical methods are promising to address the ever-increasing demands for chirality analysis in drug discovery and related fields because they are amenable to high-throughput screening. Circular dichroism-based chiroptical sensing using host-guest chemistry is especially appealing due to the fast equilibrium kinetics, wide substrate scope, and potential for sustainable development. In this Minireview, we give an overview on this emerging field. General aspects of molecular recognition and chirality transfer are analyzed. Chirality sensors are discussed by dividing them into three classes according to their structural features. Applications of these chirality sensors for chirality analysis of the products of asymmetric reactions and for the real-time monitoring of reaction kinetics are demonstrated with selected examples. Moreover, challenges and research directions in this field are also highlighted.

Automated summary

Optical methods, particularly Circular dichroism-based chiroptical sensing, show great potential in high-throughput screening for chirality analysis in drug discovery. This emerging field explores molecular recognition, chirality transfer, classification of chirality sensors, and applications in asymmetric reactions and reaction kinetics monitoring. Challenges and research directions in this area are also emphasized.