期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 23, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202202713
关键词
Asymmetric Synthesis; Bimetallic Catalysis; Chain-Walking; Protoboration; Unactivated Alkenes
资金
- NSFC [22171042, 21831002, 22193012]
- Natural Science Foundation of Jilin province [20210101134JC]
- Fundamental Research Funds for the Central Universities
- Ten Thousand Talents Program
The remote C(sp(3))-H bond asymmetric borylation of unactivated alkenes was successfully achieved by bimetallic relay catalysis, allowing the efficient synthesis of chiral organoboronates.
A remote C(sp(3))-H bond asymmetric borylation of unactivated alkenes was achieved by bimetallic relay catalysis. The reaction proceeded through reversible and consecutive beta-H elimination/olefin insertion promoted by CoH species generated in situ, followed by copper-catalyzed asymmetric protoboration. The use of this synergistic Co/Cu catalysis protocol allowed the enantioselective protoboration of various unactivated terminal alkenes and internal alkenes, as well as an unrefined mixture of olefin isomers, at the distal less-reactive beta-position to a functional group, leading to chiral organoboronates.
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