期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 30, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202205624
关键词
1; 3-Dienes; Cobalt; Enantioselective Catalysis; Hydrosilylation; Silicon-Stereogenic Center
资金
- National Natural Science Foundation of China [21702222, 21821002, 92056103]
In this study, an unprecedented cobalt-catalyzed regio-, diastereo- and enantioselective hydrosilylation of 1,3-dienes is presented, enabling the simultaneous construction of a carbon- and a silicon-stereogenic center. The generated chiral silanes exhibit high efficiency and stereoselectivity, and can be further functionalized to obtain valuable chiral building blocks.
One of the most straightforward approaches to access chiral silanes is catalytic enantioselective hydrosilylation. Although significant advances have been achieved in enantioselective construction of either a carbon-stereogenic center or a silicon-stereogenic center through enantioselective hydrosilylation, simultaneous establishment of a carbon- and a silicon-stereogenic center in an acyclic molecule through a single intermolecular hydrosilylation remained undeveloped. Herein, an unprecedented cobalt-catalyzed regio-, diastereo- and enantioselective hydrosilylation of 1,3-dienes is presented, enabling construction of a carbon- and a silicon-stereogenic center in a single intermolecular transformation. A wide range of chiral silanes bearing a carbon- and a silicon-stereogenic center were generated in high efficiency and stereoselectivity. Functionalization of the enantioenriched silanes delivered a variety of valuable chiral building blocks that are otherwise difficult to access.
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