Advances in Neuroimaging and Monitoring to Defend Cerebral Perfusion in Noncardiac Surgery

Noncardiac surgery conveys a substantial risk of secondary organ dysfunction and injury. Neurocognitive dysfunction and covert stroke are emerging as major forms of perioperative organ dysfunction, but a better understanding of perioperative neurobiology is required to identify effective treatment strategies. The likelihood and severity of perioperative brain injury may be increased by intraoperative hemodynamic dysfunction, tissue hypoperfusion, and a failure to recognize complications early in their development. Advances in neuroimaging and monitoring techniques, including optical, sonographic, and magnetic resonance, have progressed beyond structural imaging and now enable noninvasive assessment of cerebral perfusion, vascular reserve, metabolism, and neurologic function at the bedside. Translation of these imaging methods into the perioperative setting has highlighted several potential avenues to optimize tissue perfusion and deliver neuroprotection. This review introduces the methods, metrics, and evidence underlying emerging optical and magnetic resonance neuroimaging methods and discusses their potential experimental and clinical utility in the setting of noncardiac surgery.

Automated summary

Noncardiac surgery carries a significant risk of secondary organ dysfunction and injury, with neurocognitive dysfunction and covert stroke emerging as major forms of perioperative organ dysfunction. Advances in neuroimaging and monitoring techniques now allow for noninvasive assessment of cerebral perfusion and neurologic function at the bedside, providing potential avenues for optimizing tissue perfusion and delivering neuroprotection in the setting of noncardiac surgery.