pH-Sensitive Bioprobe for Multichannel Mitochondrial Imaging and Photodynamic Therapy

Review Chemistry, Inorganic & Nuclear

Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy

Chenxu Yan et al.

Summary: Recent advances in molecularly NIR fluorescent probes for nanotheranostics have attracted increasing attention due to their potential in bridging in vivo imaging and therapeutic capability within a unimolecular system. The unique advantages of near-infrared (NIR) fluorescence imaging, such as low background, deep penetration, and minimal tissue damage, make it a promising tool for in vivo chemotherapy and phototherapy. The focus is on design strategy and functionalization of high-performance fluorophores, with discussions on current challenges and future prospects in bringing forth clinical applications for personalized treatment.

COORDINATION CHEMISTRY REVIEWS (2021)

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Review Chemistry, Inorganic & Nuclear

Imaging strategies using cyanine probes and materials for biomedical visualization of live animals

Guiqiang Fei et al.

Summary: In vivo fluorescence imaging is crucial for biomedical research in living animals, and cyanine-based systems have shown promise for various applications in this field. Researchers can utilize the properties of cyanine-based systems to design a variety of functional fluorescence probes for real-time monitoring and imaging analysis in vivo.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Nanoscience & Nanotechnology

Multifunction in One Molecule: Mitochondrial Imaging and Photothermal & Photodynamic Cytotoxicity of Fast-Response Near-Infrared Fluorescent Probes with Aggregation-Induced Emission Characteristics

Lu Zhang et al.

Summary: HJS and DHJS are newly designed therapy probes that can rapidly enter cancer cells and selectively target mitochondria, exhibiting photothermal and photodynamic cytotoxicity while possessing dual-channel fluorescence imaging capability.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Nanoscience & Nanotechnology

Organelle-Targeted Photosensitizers for Precision Photodynamic Therapy

Rui Wang et al.

Summary: Targeted photodynamic therapy towards subcellular organelles presents a promising strategy for reducing side effects and enhancing therapeutic efficacy, providing implementable strategies for precision medicine in the future.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Multicolor Two-Photon Nanosystem for Multiplexed Intracellular Imaging and Targeted Cancer Therapy

Yong-Xiang Wu et al.

Summary: Novel theranostic nanosystems based on two-photon fluorescence have been designed and prepared for the diagnosis and therapy of various cancers. These nanosystems can be used for intracellular imaging and drug delivery in cancer cells, enhancing imaging depth and tissue spatial localization.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Chemistry, Inorganic & Nuclear

Photodynamic therapy for hypoxic tumors: Advances and perspectives

Li Huang et al.

Summary: Photodynamic therapy (PDT) is a preferred clinical technology for treating tumors, but the hypoxic tumor microenvironment weakens its efficiency. Strategies for improving PDT efficacy in hypoxic tumors include increasing oxygen concentration, disregarding hypoxia, and exploiting hypoxia. Combining PDT with other therapeutics can also enhance treatment outcomes.

COORDINATION CHEMISTRY REVIEWS (2021)

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Review Pharmacology & Pharmacy

Potential of Cyanine Derived Dyes in Photodynamic Therapy

Natalia Lange et al.

Summary: Photodynamic therapy (PDT) is an effective cancer treatment method that utilizes cyanine dyes and their derivatives as photosensitizers. Structural modifications of cyanine dyes aim to increase solubility in aqueous media, enhance phototoxicity, and improve treatment efficacy.

PHARMACEUTICS (2021)

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Article Chemistry, Analytical