期刊
ANALYTICAL CHEMISTRY
卷 94, 期 9, 页码 4126-4133出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.2c00306
关键词
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资金
- National Natural Science Foundation of China [22073070, 22074113]
- Young Top-notch Talent Cultivation Program of Hubei Province
- Bagui Scholar Program of Guangxi Province (2016)
Tumor targeting therapy and photodynamic therapy are effective anti-cancer therapies. The design and synthesis of multifunctional organic phototheranostic agents play an increasingly positive role in cancer diagnosis and treatment.
Tumor targeting therapy and photodynamic therapy are effective anti-cancer therapies. Their research progress has attracted wide attention and is one of the focuses of anti-cancer drug research and development. The design and synthesis of multifunctional organic phototheranostic agents for superior image-guided diagnosis and phototherapy play an increasingly positive role in cancer diagnosis and treatment. Herein, F16M and CyM were obtained through functional design from cyanine and F16. Physicochemical characterization and biological application results showed that CyM is a multifunctional organic biological probe, which can realize intracellular multichannel (green, yellow, red, and NIR) imaging, pH detection, and mitochondrial-targeted photodynamic therapy. As an organic phototheranostic agent, it could not only realize near-infrared imaging and photodynamic therapy in vivo and in vitro but also has excellent biocompatibility and good guiding significance for the development of multichannel imaging and mitochondrial-targeting photodynamic therapy.
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