期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 22, 期 7, 页码 1842-1851出版社
WILEY
DOI: 10.1111/ajt.17037
关键词
clinical research; practice; graft survival; ischemia reperfusion injury (IRI); liver allograft function; dysfunction; liver transplantation; hepatology; organ acceptance; organ perfusion and preservation; organ procurement and allocation; solid organ transplantation
Prolonged hypothermic oxygenated machine perfusion (HOPE) preservation of donor livers is safe and can lead to good outcomes in liver transplantation, with low incidence of complications and high survival rates. It can also reduce ischemia-reperfusion injury-related complications.
A short period (1-2 h) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver transplantation. Machine perfusion time is occasionally prolonged for logistical reasons, but it is unknown if prolonged HOPE is safe and compromises outcomes. We conducted a multicenter, observational cohort study of patients transplanted with a liver preserved by prolonged (>= 4 h) HOPE. Postoperative biochemistry, complications, and survival were evaluated. The cohort included 93 recipients from 12 European transplant centers between 2014-2021. The most common reason to prolong HOPE was the lack of an available operating room to start the transplant procedure. Grafts underwent HOPE for a median (range) of 4:42 h (4:00-8:35 h) with a total preservation time of 10:50 h (5:50-20:50 h). Postoperative peak ALT was 675 IU/L (interquartile range 419-1378 IU/L). The incidence of postoperative complications was low, and 1-year graft and patient survival were 94% and 88%, respectively. To conclude, good outcomes are achieved after transplantation of donor livers preserved with prolonged (median 4:42 h) HOPE, leading to a total preservation time of almost 21 h. These results suggest that simple, end-ischemic HOPE may be utilized for safe extension of the preservation time to ease transplantation logistics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据