期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 322, 期 5, 页码 R445-R453出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00319.2021
关键词
hyperoxia; hypoxia; venous capacity; venous compliance
类别
资金
- University of Auckland-Faculty Research Development Fund
- Health Research Council of New Zealand
- Sidney Taylor Trust
- Auckland District Health Board
In this study, the effects of hypoxia and hyperoxia on venous capacity and compliance in the lower limb were investigated. The results revealed that hypoxia decreased the venous capacity while hyperoxia increased venous compliance.
Blood oxygen is an important modulator of arterial function, but its impact on peripheral venous function is incompletely understood. Herein, we sought to determine the effect of hypoxia and hyperoxia on venous capacity and compliance in the lower limb. In 16 healthy individuals (7 women; age: 28.3 +/- 7.6 yr, mean +/- SD), we assessed peripheral oxygen saturation (Sp(o2)), the cross-sectional area (CSA) of the great saphenous vein (GSV; Doppler ultrasound), and calf volume (strain-gauge plethysmography) during a standard 60 mmHg thigh cuff inflation-deflation protocol. Separate trials were undertaken during breathing of room air, hypoxia [fraction in inspired oxygen (Fl(o2)): 0.10], and hyperoxia (Fl(o2): 0.50), according to a single-blinded, randomized design. Lower limb pressure-CSA and pressure-volume relationships were modeled using a quadratic regression equation and compliance derived. Sp ot was decreased by hypoxia (83.6 +/- 5.6%) and increased by hyperoxia (98.7 +/- 0.5%) compared with room air (96.4 +/- 1.0%, P < 0.001). Compared with room air (17.0 +/- 7.9 mm(2)), hypoxia decreased GSV CSA (13.4 +/- 5.7 mm(2), P < 0.001), whereas no change was observed with hyperoxia (17.1 +/- 8.7 mm(2), P = 0.883). GSV compliance derived from the pressure-CSA relationships was elevated approximately twofold with hyperoxia (-0.0061 +/- 0.0046 a.u.) when compared with room air (-0.0029 +/- 0.002 a.u., P = 0.027) and hypoxia (-0.0030 +/- 0.0032 a.u., P = 0.007). No differences were observed in calf pressure-volume parameters with either hypoxia or hyperoxia (P > 0.05). Our data indicate that GSV capacity is reduced by hypoxia, and that GSV compliance is increased by hyperoxia, thus highlighting the often overlooked role of oxygen in the regulation of venous circulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据