4.6 Review

Psychological Stress and Heart Disease: Fact or Folklore?

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AMERICAN JOURNAL OF MEDICINE
卷 135, 期 6, 页码 688-696

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjmed.2022.01.053

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Angina; Heart disease; Myocardial infarction; Myocardial ischemia; Psychological stress

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This review critically examines and summarizes the research data supporting the association between stress and cardiovascular risk. It also summarizes the potential mechanisms by which psychological stress may contribute to heart disease and precipitate myocardial ischemia and infarction.
For at least a few centuries, if not millennia, psychological stress has been popularly believed to contribute to heart disease. Does psychological stress really contribute to heart disease? Are anecdotal, patient, and lay press reports that angina, heart attack, and even cardiac death are caused by stress based on fact, or are they just folklore? In this review, the study data supporting associations between stress and cardiovascular risk, as well as potential mechanisms by which psychological stress might contribute to heart disease and precipitate myocardial ischemia and infarction, are critically reviewed and summarized. Published by Elsevier Inc.

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