期刊
AMERICAN JOURNAL OF GASTROENTEROLOGY
卷 117, 期 9, 页码 1482-1490出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.14309/ajg.0000000000001842
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资金
- Association Francois Aupetit (AFA)
This study aimed to investigate the efficacy and safety of infliximab (IFX) reintroduction in Crohn's disease (CD) after discontinuation due to loss of response or intolerance. The results showed that IFX retreatment was effective and safe in approximately one-third of patients with CD, regardless of the reason for prior discontinuation. Early detection of anti-drug antibodies could predict subsequent failure of IFX reintroduction and infusion reactions.
INTRODUCTION: The objective of this study was to describe the efficacy and safety of infliximab (IFX) reintroduction in Crohn's disease (CD) after stopping for loss of response or intolerance. METHODS: We conducted a prospective multicenter observational cohort study including adult patients with clinically (CD Activity Index >150) and objectively active luminal CD in whom IFX was reintroduced after at least 6 months of discontinuation. The reasons for the initial discontinuation could be a secondary loss of response or IFX intolerance. The reintroduction schedule included 3 IFX infusions at weeks 0, 4, and 8, after a systematic premedication. The primary end point was the efficacy of IFX retreatment at week 26 defined by a CD Activity Index of <150 in the absence of IFX discontinuation or use of corticosteroids, surgery, or other biologic. RESULTS: At week 26, 24 patients (35%) among the 69 analyzed reached the primary end point. No significant difference was observed between rates of clinical remission at week 26 in patients with prior LOR (n = 48) and those with IFX intolerance (n = 21) (35% and 33%, P = 0.87, respectively). Thirty-two acute infusion reactions were recorded in 27 patients, leading to withdrawal of IFX in 20 patients. No pharmacokinetic characteristic at baseline but detection of positive anti-drug antibodies at week 4 was predictive of IFX failure or infusion reaction at week 26. DISCUSSION: In this first prospective cohort study, IFX retreatment was safe and effective in one-third of the patients with CD, regardless the reason of prior discontinuation. Early detection of anti-drug antibodies can predict subsequent IFX reintroduction failure and infusion reactions.
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