Sex-related association of nonalcoholic fatty liver disease and liver fibrosis with body fat distribution in the general US population

Review Gastroenterology & Hepatology

Nonalcoholic fatty liver disease and risk of incident hypertension: a systematic review and meta-analysis

Stefano Ciardullo et al.

Summary: This systematic review and meta-analysis found that NAFLD is associated with a moderately increased risk of incident hypertension, with further investigation needed into the role of NAFLD severity on hypertension development.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?

Ramy Younes et al.

Summary: Lean Caucasian subjects with NAFLD may progress to advanced liver disease, develop metabolic comorbidities, and experience cardiovascular disease and liver-related mortality, independent of longitudinal progression to obesity and PNPLA3 genotype. These patients represent one end of a wide spectrum of phenotypic expression of NAFLD.

GUT (2022)

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Review Gastroenterology & Hepatology

Women Have a Lower Risk of Nonalcoholic Fatty Liver Disease but a Higher Risk of Progression vs Men: A Systematic Review and Meta-analysis

Maya Balakrishnan et al.

Summary: In a systematic review and meta-analysis, it was found that women have a lower risk of NAFLD than men. However, once NAFLD is established, women have a higher risk of advanced fibrosis than men, especially after age 50 years.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: an updated meta-analysis of 501 022 adult individuals

Alessandro Mantovani et al.

Summary: This meta-analysis shows that patients with NAFLD have a significantly increased risk of developing diabetes, and this risk rises with the severity of NAFLD. The risk is independent of age, sex, adiposity measures, and other metabolic risk factors.

GUT (2021)

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Article Gastroenterology & Hepatology

Liver fibrosis assessed by transient elastography is independently associated with albuminuria in the general United States population

Stefano Ciardullo et al.

Summary: This study found an association between liver fibrosis assessed using VCTE and CKD in the general US population, particularly with the albuminuric phenotype, regardless of traditional risk factors.

DIGESTIVE AND LIVER DISEASE (2021)

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Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update

Annalisa Berzigotti et al.

Summary: The article provides the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for assessing liver disease severity and prognosis, with a focus on topics with relevant evidence published in the last 5 years.

JOURNAL OF HEPATOLOGY (2021)

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Article Endocrinology & Metabolism