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James J. Yoo
CURRENT STEM CELL RESEARCH & THERAPY (2023)
Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma
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CANCER LETTERS (2021)
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LEUKEMIA (2021)
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LEUKEMIA (2021)
PCAT-1 contributes to cisplatin resistance in gastric cancer through epigenetically silencing PTEN via recruiting EZH2
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JOURNAL OF CELLULAR BIOCHEMISTRY (2020)
Splicing factor SF3B1 promotes endometrial cancer progression via regulating KSR2 RNA maturation
Pooja Popli et al.
CELL DEATH & DISEASE (2020)
MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells
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BMC RESEARCH NOTES (2020)
Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway
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BMC CANCER (2019)
Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells
Qianjing Zhang et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)
Targeting FAT1 Inhibits Carcinogenesis, Induces Oxidative Stress and Enhances Cisplatin Sensitivity through Deregulation of LRP5/WNT2/GSS Signaling Axis in Oral Squamous Cell Carcinoma
Tung-Nien Hsu et al.
CANCERS (2019)
Platinum Resistance in Ovarian Cancer: Role of DNA Repair
Giovanna Damia et al.
CANCERS (2019)
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action
Lorenzo I. Finci et al.
GENES & DEVELOPMENT (2018)
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds
Constantin Cretu et al.
MOLECULAR CELL (2018)
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
Michael Seiler et al.
NATURE MEDICINE (2018)
HMQ-T-F5 (1-(4-(2-aminoquinazolin-7-yl)phenyl)-3-(2-bromo-5-(trifluoromethoxy)phenyl)thiourea) suppress proliferation and migration of human cervical HeLa cells via inhibiting Wnt/β-catenin signaling pathway
Bingling Dai et al.
PHYTOMEDICINE (2018)
Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping
Gang Wu et al.
RNA (2018)
Systematic expression alteration analysis of master reprogramming factor OCT4 and its three pseudogenes in human cancer and their prognostic outcomes
Subbroto Kumar Saha et al.
SCIENTIFIC REPORTS (2018)
Aberrant RNA Splicing in Cancer and Drug Resistance
Bi-Dar Wang et al.
CANCERS (2018)
The emerging role of minor intron splicing in neurological disorders
Daniel Jutzi et al.
CELL STRESS (2018)
Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry
Kamil Makowski et al.
ACS CHEMICAL BIOLOGY (2017)
Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells
J. Yu et al.
LEUKEMIA (2017)
A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment
Ellen Siebring-van Olst et al.
MOLECULAR ONCOLOGY (2017)
Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate
Sujiet Puthenveetil et al.
PLOS ONE (2017)
Molecular basis of differential 3′ splice site sensitivity to anti-tumor drugs targeting U2 snRNP
Luisa Vigevani et al.
NATURE COMMUNICATIONS (2017)
Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6
Morgan Thurman et al.
BIOMARKER INSIGHTS (2017)
A Challenging Pie to Splice: Drugging the Spliceosome
Brian Leon et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mc1-1
M. Larrayoz et al.
LEUKEMIA (2016)
Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway
Manoj K. Kashyap et al.
ONCOTARGET (2016)
Selectivity in Small Molecule Splicing Modulation
Deepak Kumar et al.
ACS CHEMICAL BIOLOGY (2016)
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses
Alison Taylor et al.
IMMUNITY (2016)
T-REX on-demand redox targeting in live cells
Saba Parvez et al.
NATURE PROTOCOLS (2016)
Alternative splicing within the Wnt signaling pathway: role in cancer development
B. Sumithra et al.
CELLULAR ONCOLOGY (2016)
Wnt Signaling in Normal and Malignant Stem Cells
Dheeraj Bhavanasi et al.
CURRENT STEM CELL REPORTS (2016)
Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration
Moises Ramos-Solano et al.
EXPERIMENTAL CELL RESEARCH (2015)
Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B
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HAEMATOLOGICA (2015)
Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B
Manoj K. Kashyap et al.
HAEMATOLOGICA (2015)
The spliceosome: disorder and dynamics defined
Weijun Chen et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2014)
A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors
D. S. Hong et al.
INVESTIGATIONAL NEW DRUGS (2014)
Hallmarks of alternative splicing in cancer
S. Oltean et al.
ONCOGENE (2014)
Systems biology of cisplatin resistance: past, present and future
L. Galluzzi et al.
CELL DEATH & DISEASE (2014)
Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells
Yang Gao et al.
SCIENTIFIC REPORTS (2014)
Chemical Perturbation of Mcl-1 Pre-mRNA Splicing to Induce Apoptosis in Cancer Cells
Yang Gao et al.
ACS CHEMICAL BIOLOGY (2013)
Clinical and biological implications of driver mutations in myelodysplastic syndromes
Elli Papaemmanuil et al.
BLOOD (2013)
Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors
Ferry A. L. M. Eskens et al.
CLINICAL CANCER RESEARCH (2013)
Stabilized Cyclopropane Analogs of the Splicing Inhibitor FD-895
Reymundo Villa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
J. William Harbour et al.
NATURE GENETICS (2013)
p53 is activated in response to disruption of the pre-mRNA splicing machinery
N. Allende-Vega et al.
ONCOGENE (2013)
RNA sequencing of cancer reveals novel splicing alterations
Jeyanthy Eswaran et al.
SCIENTIFIC REPORTS (2013)
The spliceosome as a target of novel antitumour drugs
Sophie Bonnal et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell-Specific Tumor Suppressor for Development of Lymphomas
Machteld M. Tiemessen et al.
PLOS BIOLOGY (2012)
Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing
Liying Fan et al.
ACS CHEMICAL BIOLOGY (2011)
Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product
Makoto Hasegawa et al.
ACS CHEMICAL BIOLOGY (2011)
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
Anna Corrionero et al.
GENES & DEVELOPMENT (2011)
Activating Transcription Factor-6 (ATF6) Mediates Apoptosis with Reduction of Myeloid Cell Leukemia Sequence 1 (Mcl-1) Protein via Induction of WW Domain Binding Protein 1
Nobuhiro Morishima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation
Juan Liang et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
Lili Wang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
Desheng Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
Ana-Maria Florea et al.
Cancers (2011)
Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells
Irina Eberle et al.
NUCLEIC ACIDS RESEARCH (2010)
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
David Warde-Farley et al.
NUCLEIC ACIDS RESEARCH (2010)
Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis
J. Zhang et al.
ONCOGENE (2010)
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
Chia-Chen Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
GSK3: a multifaceted kinase in Wnt signaling
Dianqing Wu et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
Bryan T. MacDonald et al.
DEVELOPMENTAL CELL (2009)
Synthetic mRNA Splicing Modulator Compounds with in Vivo Antitumor Activity
Chandraiah Lagisetti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing
Kristine O'Brien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS
Udayan Guha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Heterogeneous expression of Wnt/β-catenin target genes within colorectal cancer
Falk Hlubek et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
Daisuke Kaida et al.
NATURE CHEMICAL BIOLOGY (2007)
How is pluripotency determined and maintained?
Hitoshi Niwa
DEVELOPMENT (2007)
Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression
Sang-Oh Yoon et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2
Peter M. Price et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
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NATURE GENETICS (2006)
Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
DS Lu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
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METHODS (2001)
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