期刊
AGING CELL
卷 21, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/acel.13589
关键词
aging; CD38; healthspan; longevity; mice; NAD; small molecule
资金
- NIH [AG-26094, AG58812 CA233790]
Inhibiting CD38 enzyme can prolong the lifespan and healthspan of aged mice, improve exercise performance, endurance, and metabolic function, with differences observed between sexes.
Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age-related NAD decline. Whether the inhibition of CD38 increases lifespan is not known. Here, we show that the CD38 inhibitor 78c increases lifespan and healthspan of naturally aged mice. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between sexes. Our study is the first to investigate the effect of CD38 inhibition in naturally aged animals.
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