相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Fine-mapping of Parkinson's disease susceptibility loci identifies putative causal variants
Brian M. Schilder et al.
HUMAN MOLECULAR GENETICS (2022)
Multi-omic insights into Parkinson's Disease: From genetic associations to functional mechanisms
Brian M. M. Schilder et al.
NEUROBIOLOGY OF DISEASE (2022)
Multi-omic landscaping of human midbrains identifies disease-relevant molecular targets and pathways in advanced-stage Parkinson's disease
Lucas Caldi Gomes et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2022)
Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease
Emmeline E. Brown et al.
NEUROBIOLOGY OF AGING (2021)
Genetic ancestry plays a central role in population pharmacogenomics
Hsin-Chou Yang et al.
COMMUNICATIONS BIOLOGY (2021)
Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease
Dongbing Lai et al.
ANNALS OF NEUROLOGY (2021)
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease
Ganqiang Liu et al.
NATURE GENETICS (2021)
Association of NO2 and Other Air Pollution Exposures With the Risk of Parkinson Disease
Sungyang Jo et al.
JAMA NEUROLOGY (2021)
Characterizing the Genetic Architecture of Parkinson's Disease in Latinos
Douglas P. Loesch et al.
ANNALS OF NEUROLOGY (2021)
Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease
Manuela M. X. Tan et al.
MOVEMENT DISORDERS (2021)
The genetic architecture of Parkinson's disease
Cornelis Blauwendraat et al.
LANCET NEUROLOGY (2020)
Mendelian Randomization-A Journey From Obscurity to Center Stage With a Few Potholes Along the Way
Sara Bandres-Ciga et al.
JAMA NEUROLOGY (2020)
A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits
Andy Dahl et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2020)
Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk
Dheeraj Reddy Bobbili et al.
JOURNAL OF MEDICAL GENETICS (2020)
Ten Years of the International Parkinson Disease Genomics Consortium: Progress and Next Steps
Andrew Singleton
JOURNAL OF PARKINSONS DISEASE (2020)
Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans A Genome-Wide Association Study
Jia Nee Foo et al.
JAMA NEUROLOGY (2020)
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Julien Bryois et al.
NATURE GENETICS (2020)
Modeling the complex genetic architectures of brain disease
Michael B. Fernando et al.
NATURE GENETICS (2020)
Genetics of Parkinson's disease: An introspection of its journey towards precision medicine
Sara Bandres-Ciga et al.
NEUROBIOLOGY OF DISEASE (2020)
Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
S. Bandres-Ciga et al.
ACTA NEUROPATHOLOGICA (2020)
Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research
Roopa Rajan et al.
FRONTIERS IN NEUROLOGY (2020)
Penetrance of Glucocerebrosidase (GBA) Mutations in Parkinson's Disease: a Kin Cohort Study
Roberta Balestrino et al.
MOVEMENT DISORDERS (2020)
Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank
Benjamin Meir Jacobs et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)
Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci
Johannes Jernqvist Gaare et al.
PLOS ONE (2020)
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
Devika Agarwal et al.
NATURE COMMUNICATIONS (2020)
LRRK2 and the Endolysosomal System in Parkinson's Disease
Madalynn L. Erb et al.
JOURNAL OF PARKINSONS DISEASE (2020)
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease
Laura Ibanez et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
MTOR Pathway-Based Discovery of Genetic Susceptibility to L-DOPA-Induced Dyskinesia in Parkinson's Disease Patients
Nuria Martin-Flores et al.
MOLECULAR NEUROBIOLOGY (2019)
Concordance for Parkinson's disease in twins: A 20-year update
Samuel M. Goldman et al.
ANNALS OF NEUROLOGY (2019)
Gene-Environment Interaction in the Era of Precision Medicine
Jingjing Li et al.
CELL (2019)
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
Sara Bandres-Ciga et al.
MOVEMENT DISORDERS (2019)
The distribution and risk effect of GBA variants in a large cohort of PD patients from Colombia and Peru
Carlos Velez-Pardo et al.
PARKINSONISM & RELATED DISORDERS (2019)
Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains
Eilis Hannon et al.
MOLECULAR BRAIN (2019)
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms
Cornelis Blauwendraat et al.
MOVEMENT DISORDERS (2019)
Benefits and limitations of genome-wide association studies
Vivian Tam et al.
NATURE REVIEWS GENETICS (2019)
SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease
Ruben Fernandez-Santiago et al.
MOVEMENT DISORDERS (2019)
Genetic correlations of polygenic disease traits: from theory to practice
Wouter van Rheenen et al.
NATURE REVIEWS GENETICS (2019)
Progress in the genetic analysis of Parkinson's disease
Andrew Singleton et al.
HUMAN MOLECULAR GENETICS (2019)
Update of the MDS research criteria for prodromal Parkinson's disease
Sebastian Heinzel et al.
MOVEMENT DISORDERS (2019)
The Parkinson's Disease Mendelian Randomization Research Portal
Alastair J. Noyce et al.
MOVEMENT DISORDERS (2019)
The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight
Sara Bandres-Ciga et al.
MOVEMENT DISORDERS (2019)
PD-linked CHCHD2 mutations impair CHCHD10 and a MICOS complex leading to mitochondria dysfunction
Wei Zhou et al.
HUMAN MOLECULAR GENETICS (2019)
Understanding the role of genetic variability in LRRK2 in Indian population
Asha Kishore et al.
MOVEMENT DISORDERS (2019)
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Mike A. Nalls et al.
LANCET NEUROLOGY (2019)
The Role of Rare Coding Variants in Parkinson's Disease GWAS Loci
Elisaebeth Luisa Germer et al.
FRONTIERS IN NEUROLOGY (2019)
Lessons Learned From GWAS of Asthma
Kyung Won Kim et al.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2019)
α-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain
Ruben Fernandez-Santiago et al.
MOVEMENT DISORDERS (2018)
Using genetic data to strengthen causal inference in observational research
Jean-Baptiste Pingault et al.
NATURE REVIEWS GENETICS (2018)
Integrated Genetic Analysis of Racial Differences of Common GBA Variants in Parkinson's Disease: A Meta-Analysis
Yuan Zhang et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
Angli Xue et al.
NATURE COMMUNICATIONS (2018)
Advances in Parkinson's Disease: 200 Years Later
Natalia Lopez-Gonzalez Del Rey et al.
FRONTIERS IN NEUROANATOMY (2018)
The Emerging Evidence of the Parkinson Pandemic
E. Ray Dorsey et al.
JOURNAL OF PARKINSONS DISEASE (2018)
Genome-Wide Association Studies of Cancer in Diverse Populations
Sungshim L. Park et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2018)
Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts
Ganqiang Liu et al.
LANCET NEUROLOGY (2017)
LARGE-PD: Examining the Genetics of Parkinson's Disease in Latin America
Cyrus P. Zabetian et al.
MOVEMENT DISORDERS (2017)
PREDICT-PD: An online approach to prospectively identify risk indicators of Parkinson's disease
Alastair J. Noyce et al.
MOVEMENT DISORDERS (2017)
Penetrance Estimate of LRRK2 p.G2019S Mutation in Individuals of Non-Ashkenazi Jewish Ancestry
Annie J. Lee et al.
MOVEMENT DISORDERS (2017)
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Diana Chang et al.
NATURE GENETICS (2017)
The two-century journey of Parkinson disease research
Serge Przedborski
NATURE REVIEWS NEUROSCIENCE (2017)
Establishing the role of rare coding variants in known Parkinson's disease risk loci
Iris E. Jansen et al.
NEUROBIOLOGY OF AGING (2017)
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study
Lisa Wang et al.
NEUROBIOLOGY OF AGING (2017)
Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study
Alastair J. Noyce et al.
PLOS MEDICINE (2017)
Can machine-learning improve cardiovascular risk prediction using routine clinical data?
Stephen F. Weng et al.
PLOS ONE (2017)
Pooled analysis of the HLA-DRB1 by smoking interaction in Parkinson disease
Yu-Hsuan Chuang et al.
ANNALS OF NEUROLOGY (2017)
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease
Laurie A. Robak et al.
BRAIN (2017)
A powerful and efficient two-stage method for detecting gene-to-gene interactions in GWAS
Jakub Pecanka et al.
BIOSTATISTICS (2017)
Loss of VPS1 3C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy
Suzanne Lesage et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2016)
DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study
Joanne Trinh et al.
LANCET NEUROLOGY (2016)
Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies
Maria Xilouri et al.
MOVEMENT DISORDERS (2016)
A cumulative genetic risk score predicts progression in Parkinson's disease
Lasse Pihlstrom et al.
MOVEMENT DISORDERS (2016)
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
Frank Soldner et al.
NATURE (2016)
G = E: What GWAS Can Tell Us about the Environment
Suzanne H. Gage et al.
PLOS GENETICS (2016)
A new gene for Parkinson's disease: should we care?
Andrew Singleton
LANCET NEUROLOGY (2015)
Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study
Mike A. Nalls et al.
LANCET NEUROLOGY (2015)
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study
Manabu Funayama et al.
LANCET NEUROLOGY (2015)
Genetic risk and age in Parkinson's disease: Continuum not stratum
Mike A. Nalls et al.
MOVEMENT DISORDERS (2015)
MDS research criteria for prodromal Parkinson's disease
Daniela Berg et al.
MOVEMENT DISORDERS (2015)
Partitioning heritability by functional annotation using genome-wide association summary statistics
Hilary K. Finucane et al.
NATURE GENETICS (2015)
Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease - Report of the JPND Working Group BioLoC-PD
Stefanie Lerche et al.
NEUROEPIDEMIOLOGY (2015)
Age-specific penetrance of LRRK2 G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium
Karen Marder et al.
NEUROLOGY (2015)
Amyotrophic Lateral Sclerosis Onset Is Influenced by the Burden of Rare Variants in Known Amyotrophic Lateral Sclerosis Genes
Janet Cady et al.
ANNALS OF NEUROLOGY (2015)
Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease
Karen E. Murphy et al.
BRAIN (2014)
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
Mike A. Nalls et al.
NATURE GENETICS (2014)
LRRK2 PARKINSONISM IN TUNISIA AND NORWAY: A COMPARATIVE ANALYSIS OF DISEASE PENETRANCE
Faycel Hentati et al.
NEUROLOGY (2014)
Comparison of Parkinson Risk in Ashkenazi Jewish Patients With Gaucher Disease and GBA Heterozygotes
Roy N. Alcalay et al.
JAMA NEUROLOGY (2014)
A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinsons disease
Peter Holmans et al.
HUMAN MOLECULAR GENETICS (2013)
The Sac1 Domain of SYNJ1 Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures
Catharine E. Krebs et al.
HUMAN MUTATION (2013)
Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study
Alex Iranzo et al.
LANCET NEUROLOGY (2013)
The current and projected economic burden of Parkinson's disease in the United States
Stacey L. Kowal et al.
MOVEMENT DISORDERS (2013)
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
Victoria S. Burchell et al.
NATURE NEUROSCIENCE (2013)
Correction: Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study
Irene Pichler et al.
PLOS MEDICINE (2013)
Parkin Disease A Clinicopathologic Entity?
Karen M. Doherty et al.
JAMA NEUROLOGY (2013)
Ultrafast genome-wide scan for SNP-SNP interactions in common complex disease
Snehit Prabhu et al.
GENOME RESEARCH (2012)
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease
Margaux F. Keller et al.
HUMAN MOLECULAR GENETICS (2012)
A clinical and family history study of Parkinson's disease in heterozygous glucocerebrosidase mutation carriers
Alisdair McNeill et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)
Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers
M. Anheim et al.
NEUROLOGY (2012)
Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants
Chaodong Wang et al.
PARKINSONISM & RELATED DISORDERS (2012)
A Deleterious Mutation in DNAJC6 Encoding the Neuronal-Specific Clathrin-Uncoating Co-Chaperone Auxilin, Is Associated with Juvenile Parkinsonism
Simon Edvardson et al.
PLOS ONE (2012)
Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways
Mark R. Cookson
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
Alexander Zimprich et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
VPS35 Mutations in Parkinson Disease
Carles Vilarino-Gueell et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
The incidence of Parkinsonism in patients with type 1 Gaucher disease: Data from the ICGG Gaucher Registry
Barry Rosenbloom et al.
BLOOD CELLS MOLECULES AND DISEASES (2011)
Cost of disorders of the brain in Europe 2010
Anders Gustavsson et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2011)
A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci
Andrew Singleton et al.
HUMAN MOLECULAR GENETICS (2011)
Association of LRRK2 exonic variants and susceptibility to Parkinson's disease: a case-control study (vol 10, pg 898, 2011)
O. A. Ross et al.
LANCET NEUROLOGY (2011)
High frequency and reduced penetrance of lRRK2 g2019S mutation among Parkinson's disease patients in Cantabria (Spain)
Maria Sierra et al.
MOVEMENT DISORDERS (2011)
Heritability of Parkinson disease in Swedish twins: a longitudinal study
Karin Wirdefeldt et al.
NEUROBIOLOGY OF AGING (2011)
A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease
Vincent Plagnol et al.
PLOS GENETICS (2011)
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study
Owen A. Ross et al.
LANCET NEUROLOGY (2011)
Improvement of Risk Prediction by Genomic Profiling: Reclassification Measures Versus the Area Under the Receiver Operating Characteristic Curve
Raluca Mihaescu et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2010)
REM sleep behavior disorder Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions
Bradley F. Boeve
YEAR IN NEUROLOGY 2 (2010)
Penetrance in Parkinson's Disease Related to the LRRK2 R1441G Mutation in the Basque Country (Spain)
Javier Ruiz-Martinez et al.
MOVEMENT DISORDERS (2010)
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Taye H. Hamza et al.
NATURE GENETICS (2010)
Analysing biological pathways in genome-wide association studies
Kai Wang et al.
NATURE REVIEWS GENETICS (2010)
VIEWPOINT Missing heritability and strategies for finding the underlying causes of complex disease
Evan E. Eichler et al.
NATURE REVIEWS GENETICS (2010)
Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease
Kai Wang et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
Characterization of PLA2G6 as a Locus for Dystonia-Parkinsonism
Coro Paisan-Ruiz et al.
ANNALS OF NEUROLOGY (2009)
Common vs. rare allele hypotheses for complex diseases
Nicholas J. Schork et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2009)
The Evolution of Epistasis and Its Links With Genetic Robustness, Complexity and Drift in a Phenotypic Model of Adaptation
Pierre-Alexis Gros et al.
GENETICS (2009)
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Wataru Satake et al.
NATURE GENETICS (2009)
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Javier Simon-Sanchez et al.
NATURE GENETICS (2009)
Detecting gene-gene interactions that underlie human diseases
Heather J. Cordell
NATURE REVIEWS GENETICS (2009)
FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome
A. Di Fonzo et al.
NEUROLOGY (2009)
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
E. Sidransky et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Interpretation of Genetic Association Studies: Markers with Replicated Highly Significant Odds Ratios May Be Poor Classifiers
Johanna Jakobsdottir et al.
PLOS GENETICS (2009)
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Daniel G. Healy et al.
LANCET NEUROLOGY (2008)
Linkage disequilibrium - understanding the evolutionary past and mapping the medical future
Montgomery Slatkin
NATURE REVIEWS GENETICS (2008)
Genome-Wide Prediction of Functional Gene-Gene Interactions Inferred from Patterns of Genetic Differentiation in Mice and Men
Zoltan Bochdanovits et al.
PLOS ONE (2008)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Alfredo Ramirez et al.
NATURE GENETICS (2006)
Why most published research findings are false
JPA Ioannidis
PLOS MEDICINE (2005)
Complement factor H polymorphism in age-related macular degeneration
RJ Klein et al.
SCIENCE (2005)
Gene-environment interactions in human diseases
DJ Hunter
NATURE REVIEWS GENETICS (2005)
Idiopathic hyposmia as a preclinical sign of Parkinson's disease
MM Ponsen et al.
ANNALS OF NEUROLOGY (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Familial aggregation of Parkinson's disease: The Mayo Clinic family study
WA Rocca et al.
ANNALS OF NEUROLOGY (2004)
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
V Bonifati et al.
SCIENCE (2003)
The ubiquitous nature of epistasis in determining susceptibility to common human diseases
JH Moore
HUMAN HEREDITY (2003)
A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease
MA Hernán et al.
ANNALS OF NEUROLOGY (2002)
The structure of haplotype blocks in the human genome
SB Gabriel et al.
SCIENCE (2002)
Haplotype tagging for the identification of common disease genes
GCL Johnson et al.
NATURE GENETICS (2001)
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
MD Ritchie et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Implications of the Human Genome Project for medical science
FS Collins et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)
Familial aggregation of Parkinson's disease in Iceland.
S Sveinbjörnsdóttir et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
分享论文
