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Philippe de Medina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
Ruth Luthi-Carter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Cholesterol trafficking is required for mTOR activation in endothelial cells
Jing Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells
Bhanu Dasari et al.
BMC OPHTHALMOLOGY (2010)
Mitochondrial DNA Damage Induced by 7-Ketocholesterol in Human Retinal Pigment Epithelial Cells In Vitro
Ana L. Gramajo et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)
The role of epigenetics in aging and age-related diseases
Vincenzo Calvanese et al.
AGEING RESEARCH REVIEWS (2009)
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
Evan T. Powers et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Is the oxidative stress theory of aging dead?
Viviana I. Perez et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)
Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells
Valerie Riendeau et al.
FREE RADICAL RESEARCH (2009)
Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases
Philippe de Medina et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Brain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase-1
Jacob R. Hascalovici et al.
JOURNAL OF NEUROCHEMISTRY (2009)
AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols
Jin-Taek Hwang et al.
NEW BIOTECHNOLOGY (2009)
MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
Jan H. J. Hoeijmakers
NEW ENGLAND JOURNAL OF MEDICINE (2009)
CELL BIOLOGY Stress Response and Aging
Laura R. Saunders et al.
SCIENCE (2009)
Why have antioxidants failed in clinical trials?
Steven R. Steinhubl
AMERICAN JOURNAL OF CARDIOLOGY (2008)
Stress-response hormesis and aging: That which Does Not Kill Us Makes Us Stronger
David Gems et al.
CELL METABOLISM (2008)
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
Carolyn D. DuSell et al.
MOLECULAR ENDOCRINOLOGY (2008)
Autophagy fights disease through cellular self-digestion
Noboru Mizushima et al.
NATURE (2008)
Purified NPC1 protein - I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein
Rodney E. Infante et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo
Tara L. Aghaloo et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2007)
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
Xiaoling Li et al.
MOLECULAR CELL (2007)
Regulation and expression of human CYP7131 in prostate:: Overexpression of CYP7131 during progression of prostatic adenocarcinoma
Mats Olsson et al.
PROSTATE (2007)
Oxysterols are substrates for cholesterol sulfotransferase
Hirotoshi Fuda et al.
JOURNAL OF LIPID RESEARCH (2007)
Cholesterol reduction yields clinical benefits: Meta-analysis including recent trials
A. Lawrence Gould et al.
CLINICAL THERAPEUTICS (2007)
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig
Arun Radhakrishnan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Oxysterols pathway in are novel activators of the hedgehog pluripotent mesenchymal cells
Jennifer R. Dwyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
Birgit Gerisch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Epigenetics: A landscape takes shape
Aaron D. Goldberg et al.
CELL (2007)
Induction of Adaptive Response and Enhancement of PC12 Cell Tolerance by 7-Hydroxycholesterol and 15-Deoxy-Δ12,14-Prostaglandin J2 through Up-regulation of Cellular Glutathione via Different Mechanisms
Zhi-Hua Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients
Celine Prunet et al.
CYTOMETRY PART A (2006)
Role of intestinal sterol transporters Abcg5, Abcg8, and Npc111 in cholesterol absorption in mice: gender and age effects
LP Duan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Cholestane-3β,5α,6β-triol inhibits osteoblastic differentiation and promotes apoptosis of rat bone marrow stromal cells
HM Liu et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2005)
TNF-α activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol
HS Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
C-elegans DAF-12, nuclear hormone receptors and human longevity and disease at old age
SP Mooijaart et al.
AGEING RESEARCH REVIEWS (2005)
Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation
YW Cheng et al.
FOOD AND CHEMICAL TOXICOLOGY (2005)
Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols
S Lemaire-Ewing et al.
CELL BIOLOGY AND TOXICOLOGY (2005)
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
IM Conboy et al.
NATURE (2005)
Oxysterols regulate differentiation of mesenchymal stem cells: Pro-bone and anti-fat
HT Kha et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2004)
Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation
F Biasi et al.
FASEB JOURNAL (2004)
Mechanisms of inflammation: The good, the bad and the ugly
FS Laroux
FRONTIERS IN BIOSCIENCE-LANDMARK (2004)
NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells
E Pedruzzi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
M Heverin et al.
JOURNAL OF LIPID RESEARCH (2004)
Unique lipoprotein phenotype and genotype associated with exceptional longevity
N Barzilai et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)
Impairment of the cytotoxic and oxidative activities of 7β-hydroxycholesterol and 7-ketocholesterol by esterification with oleate
S Monier et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
22R-hydroxycholesterol protects neuronal cells from β-amyloid-induced cytotoxicity by binding to β-amyloid peptide
ZX Yao et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Oxysterols induce interleukin-1 beta production in human macrophages
T Rosklint et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2002)
Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E
M Rosenblat et al.
ATHEROSCLEROSIS (2002)
What is apoptosis, and why is it important?
AG Renehan et al.
BMJ-BRITISH MEDICAL JOURNAL (2001)
Mesenchymal stem cells: building blocks for molecular medicine in the 21st century
AI Caplan et al.
TRENDS IN MOLECULAR MEDICINE (2001)
Oxysterols: Modulators of cholesterol metabolism and other processes
GJ Schroepfer
PHYSIOLOGICAL REVIEWS (2000)