4.7 Review

GDF15, an emerging key player in human aging

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Summary: Aging is associated with decreased muscle mass and strength, as well as elevated levels of circulating cytokines such as GDF15. In this study, higher levels of GDF15 were found in male patients compared to female patients, and elevated GDF15 concentrations were correlated with lower muscle mass, particularly in men.

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Yuta Myojin et al.

Summary: The study suggests that in the HCC microenvironment, the increase of HSCs producing GDF15 in an autophagy-dependent manner may be involved in tumor progression, while GDF15 deficiency can reduce the size of liver tumors caused by the steatohepatitis-based tumorigenesis model.

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