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A spectrum of exercise training reduces soluble A beta in a dose-dependent manner in a mouse model of Alzheimer's disease
Kaitlin M. Moore et al.
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Running rewires the neuronal network of adult-born dentate granule cells
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Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults
Anne Maass et al.
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Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later
Nicole L. Spartano et al.
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PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model
Loukia Katsouri et al.
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Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease
Matthew R. Brier et al.
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Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia
Matthew P. Pase et al.
STROKE (2016)
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis
Y. Iturria-Medina et al.
NATURE COMMUNICATIONS (2016)
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Sama F. Sleiman et al.
ELIFE (2016)
Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Ravi V. Shah et al.
JAMA INTERNAL MEDICINE (2016)
Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
Jinte Middeldorp et al.
JAMA NEUROLOGY (2016)
The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis
Adam Dinoff et al.
PLOS ONE (2016)
Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial
Kristine Hoffmann et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Gender and incidence of dementia in the Framingham Heart Study from mid-adult life
Genevieve Chene et al.
ALZHEIMERS & DEMENTIA (2015)
Improved Cardiorespiratory Fitness Is Associated with Increased Cortical Thickness in Mild Cognitive Impairment
Katherine Reiter et al.
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A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Tiia Ngandu et al.
LANCET (2015)
Separate Effects of Intensity and Amount of Exercise on Interindividual Cardiorespiratory Fitness Response
Robert Ross et al.
MAYO CLINIC PROCEEDINGS (2015)
Immune attack: the role of inflammation in Alzheimer disease
Frank L. Heppner et al.
NATURE REVIEWS NEUROSCIENCE (2015)
TREADMILL EXERCISE ENHANCES SYNAPTIC PLASTICITY, BUT DOES NOT ALTER β-AMYLOID DEPOSITION IN HIPPOCAMPI OF AGED APP/PS1 TRANSGENIC MICE
G. Zhao et al.
NEUROSCIENCE (2015)
Exercise-mimetic AICAR transiently benefits brain function
Davide Guerrieri et al.
ONCOTARGET (2015)
A meta-analysis of prospective studies on the role of physical activity and the prevention of Alzheimer's disease in older adults
Michael W. Beckett et al.
BMC GERIATRICS (2015)
Vascular hippocampal plasticity after aerobic exercise in older adults
A. Maass et al.
MOLECULAR PSYCHIATRY (2015)
Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled Trial
Eric D. Vidoni et al.
PLOS ONE (2015)
Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Xiaochen Lin et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2015)
Recent advances in the application of metabolomics to Alzheimer's Disease
Eugenia Trushina et al.
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Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Leandro Z. Agudelo et al.
CELL (2014)
Acute Aerobic Exercise Increases Brain-Derived Neurotrophic Factor Levels in Elderly with Alzheimer's Disease
Flavia Gomes de Melo Coelho et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins
Masaki Takimoto et al.
JOURNAL OF APPLIED PHYSIOLOGY (2014)
Association between mid- to late life physical fitness and dementia: evidence from the CAIDE study
J. Kulmala et al.
JOURNAL OF INTERNAL MEDICINE (2014)
Cardiorespiratory Fitness and Accelerated Cognitive Decline With Aging
Carrington R. Wendell et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Saul A. Villeda et al.
NATURE MEDICINE (2014)
Physical activity attenuates age-related biomarker alterations in preclinical AD
Ozioma C. Okonkwo et al.
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PHYSICAL ACTIVITY, INFLAMMATION, AND VOLUME OF THE AGING BRAIN
M. N. Braskie et al.
NEUROSCIENCE (2014)
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Lida Katsimpardi et al.
SCIENCE (2014)
Alzheimer's disease drug-development pipeline: few candidates, frequent failures
Jeffrey L. Cummings et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
The Association Between Midlife Cardiorespiratory Fitness Levels and Later-Life Dementia
Laura F. DeFina et al.
ANNALS OF INTERNAL MEDICINE (2013)
Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice
Hui-li Liu et al.
BEHAVIOURAL BRAIN RESEARCH (2013)
Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway
Christiane D. Wrann et al.
CELL METABOLISM (2013)
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
Clifford R. Jack et al.
LANCET NEUROLOGY (2013)
Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
B. M. Brown et al.
MOLECULAR PSYCHIATRY (2013)
Exercise Training for Blood Pressure: A Systematic Review and Meta-analysis
Veronique A. Cornelissen et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2013)
Leisure-time physical activity over the life course and cognitive functioning in late mid-adult years: a cohort-based investigation
A. Dregan et al.
PSYCHOLOGICAL MEDICINE (2013)
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease
Baiyang Sheng et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Peter T. Nelson et al.
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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Bostroem et al.
NATURE (2012)
Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years
Eric D. Vidoni et al.
NEUROBIOLOGY OF AGING (2012)
Plasma BDNF Is Associated with Age-Related White Matter Atrophy but Not with Cognitive Function in Older, Non-Demented Adults
Ira Driscoll et al.
PLOS ONE (2012)
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
Aiwu Cheng et al.
NATURE COMMUNICATIONS (2012)
Exercise training increases mitochondrial biogenesis in the brain
Jennifer L. Steiner et al.
JOURNAL OF APPLIED PHYSIOLOGY (2011)
Physical activity and risk of cognitive decline: a meta-analysis of prospective studies
F. Sofi et al.
JOURNAL OF INTERNAL MEDICINE (2011)
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Saul A. Villeda et al.
NATURE (2011)
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Alan H. Nagahara et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults: Guidance for Prescribing Exercise
Carol Ewing Garber et al.
MEDICINE & SCIENCE IN SPORTS & EXERCISE (2011)
EXERCISE INFLUENCES HIPPOCAMPAL PLASTICITY BY MODULATING BRAIN-DERIVED NEUROTROPHIC FACTOR PROCESSING
Q. Ding et al.
NEUROSCIENCE (2011)
Lactate infusion at rest increases BDNF blood concentration in humans
Thorsten Schiffer et al.
NEUROSCIENCE LETTERS (2011)
Exercise training increases size of hippocampus and improves memory
Kirk I. Erickson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Exercise and Alzheimer's Disease Biomarkers in Cognitively Normal Older Adults
Kelvin Y. Liang et al.
ANNALS OF NEUROLOGY (2010)
Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume
Kirk I. Erickson et al.
JOURNAL OF NEUROSCIENCE (2010)
Physical Activity Over the Life Course and Its Association with Cognitive Performance and Impairment in Old Age
Laura E. Middleton et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2010)
The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: A longitudinal SPECT study
Haruo Hanyu et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2010)
The effect of midlife physical activity on structural brain changes in the elderly
Suvi Rovio et al.
NEUROBIOLOGY OF AGING (2010)
Role of Lifestyle and Aging on the Longitudinal Change in Cardiorespiratory Fitness
Andrew S. Jackson et al.
ARCHIVES OF INTERNAL MEDICINE (2009)
Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women A Meta-analysis
Satoru Kodama et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence
M. Hamer et al.
PSYCHOLOGICAL MEDICINE (2009)
Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake
Jennifer A. Calvo et al.
JOURNAL OF APPLIED PHYSIOLOGY (2008)
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
Erik D. Roberson et al.
SCIENCE (2007)
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Ana C. Pereira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Running induces widespread structural alterations in the hippocampus and Entorhinal cortex
Alexis M. Stranahan et al.
HIPPOCAMPUS (2007)
Aerobic exercise training increases brain volume in aging humans
Stanley J. Colcombe et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2006)
Neuropathology of older persons without cognitive impairment from two community-based studies
D. A. Bennett et al.
NEUROLOGY (2006)
Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus
VA Redila et al.
NEUROSCIENCE (2006)
Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
Q. Ding et al.
NEUROSCIENCE (2006)
Exercise enhances learning and hippocampal neurogenesis in aged mice
H van Praag et al.
JOURNAL OF NEUROSCIENCE (2005)
Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam study
A Ruitenberg et al.
ANNALS OF NEUROLOGY (2005)
Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density
BD Eadie et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2005)
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
PA Adlard et al.
JOURNAL OF NEUROSCIENCE (2005)
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes?
E Steen et al.
JOURNAL OF ALZHEIMERS DISEASE (2005)
Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
M Ingelsson et al.
NEUROLOGY (2004)
Effect of exercise training on endothelium-derived nitric oxide function in humans
DJ Green et al.
JOURNAL OF PHYSIOLOGY-LONDON (2004)
Insulin-like growth factor I is required for vessel remodeling in the adult brain
C Lopez-Lopez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
S Vaynman et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo
J Farmer et al.
NEUROSCIENCE (2004)
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
C Schmidt-Hieber et al.
NATURE (2004)
VEGF is necessary for exercise-induced adult hippocampal neurogenesis
K Fabel et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults
DE Barnes et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2003)
Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat
RA Swain et al.
NEUROSCIENCE (2003)
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
KL Jin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
The human hippocampus and spatial and episodic memory
N Burgess et al.
NEURON (2002)
Effect of aerobic exercise on blood pressure: A meta-analysis of randomized, controlled trials
SP Whelton et al.
ANNALS OF INTERNAL MEDICINE (2002)
Exercise capacity and mortality among men referred for exercise testing
J Myers et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Functional neurogenesis in the adult hippocampus
H van Praag et al.
NATURE (2002)
Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus
JL Trejo et al.
JOURNAL OF NEUROSCIENCE (2001)
Rates of hippocampal atrophy correlate with change in clinical status in aging and AD
CR Jack et al.
NEUROLOGY (2000)
Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
J Näslund et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)